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Invitrogen
p130Cas Polyclonal Antibody
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Product Details
PA5-83601
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BCAR1. Recombinant protein control fragment (Product #RP-88613).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SPQFQSPPAK QTSTFSKQTP HHPFPSPATD LYQVPPGPGG PAQDIYQVPP SAGMGHDIYQ VPPSMDTRSW EGTKPPAKVV VPTRVGQGYV YEAAQPEQDE YD
Highest antigen sequence indentity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BCA1; BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; Breast cancer anti-estrogen resistance protein 1; Cas scaffolding protein family member 1; CRK-associated substrate; Crk-associated substrate p130Cas; OTTHUMP00000174941; p130 Cas; p130cas; p130Cas (pTyr410); p130Cas (pY410); p130Cas phospho; phospho p130Cas; unnamed protein product; v-crk-associated tyrosine kinase substrate
Gene Aliases: AI385681; BCAR1; CAS; CAS1; CASS1; CRKAS; P130Cas
UniProt ID: (Human) P56945, (Mouse) Q61140
Entrez Gene ID: (Human) 9564, (Mouse) 12927
regulation of cell growth
actin filament organization
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
insulin receptor signaling pathway
positive regulation of endothelial cell migration
cell migration
positive regulation of cell migration
cellular response to hepatocyte growth factor stimulus
regulation of apoptotic process
platelet-derived growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
hepatocyte growth factor receptor signaling pathway
antigen receptor-mediated signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
cell division
cell chemotaxis
endothelin receptor signaling pathway
actin cytoskeleton organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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