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Invitrogen
ATP5A1 Polyclonal Antibody
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FIGURE: 1 / 6
ATP5A1 Antibody (PA5-83711) in IHC (P)
Immunohistochemistry analysis of ATP5A1 in human fallopian tube, gastrointestinal, heart muscle and kidney. Samples were incubated with ATP5A1 polyclonal antibody (Product # PA5-83711). Shows similar protein distribution across tissues to independent ATP5A1 antibody (Product # PA5-83505) (B).
Product Details
PA5-83711
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ATP5A1. Recombinant protein control fragment (Product #RP-102960).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SILEERILGA DTSVDLEETG RVLSIGDGIA RVHGLRNVQA EEMVEFSSGL KGMSLNLEPD NVGVVVFGND KLIKEGDIVK RTGAIVDVPV GEELLGRVVD
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 99%.
Target Information
The ATP5F1A gene (ATP Synthase F1 Subunit Alpha) is located on chromosome 18q21.33 and encodes a critical component of the mitochondrial ATP synthase complex, specifically the F1 catalytic core. The ATP synthase complex is essential for cellular energy production, facilitating the conversion of ADP to ATP during oxidative phosphorylation. The ATP5F1A subunit is responsible for the catalysis of ATP synthesis driven by the proton gradient across the inner mitochondrial membrane. Dysfunctions or mutations in ATP5F1A can result in mitochondrial disorders and are linked to various metabolic and neurodegenerative diseases. Understanding the structure and function of ATP5F1A is vital for comprehending the bioenergetics of cellular respiration and has implications in studying mitochondrial pathologies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP synthase alpha chain, mitochondrial; ATP synthase F(1) complex subunit alpha, mitochondrial; ATP synthase F1 subunit alpha; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP sythase (F1-ATPase) alpha subunit; epididymis secretory sperm binding protein Li 123m; iso; mitochondrial ATP synthetase, oligomycin-resistant; unnamed protein product
Gene Aliases: ATP5A; ATP5A1; ATP5AL2; ATP5F1A; ATPM; COXPD22; hATP1; HEL-S-123m; MC5DN4; MC5DN4A; MC5DN4B; MOM2; OMR; ORM
UniProt ID: (Human) P25705
Entrez Gene ID: (Human) 498
negative regulation of endothelial cell proliferation
lipid metabolic process
ATP biosynthetic process
ion transport
response to muscle activity
ATP synthesis coupled proton transport
mitochondrial ATP synthesis coupled proton transport
positive regulation of blood vessel endothelial cell migration
response to ethanol
ATP metabolic process
cellular response to dexamethasone stimulus
cellular response to nitric oxide
hydrogen ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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