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Invitrogen
PKC epsilon Polyclonal Antibody
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Product Details
PA5-83725
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PRKCE. Recombinant protein control fragment (Product #RP-102967).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PPFKPRIKTK RDVNNFDQDF TREEPVLTLV DEAIVKQINQ EEFKGFSYFG EDLMP
Highest antigen sequence indentity to the following orthologs: Rat - 98%, Mouse - 96%.
Target Information
The PKC family of serine/threonine kinases, including PRKCE (PKC epsilon), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC125656; MGC125657; nPKC-epsilon; PKC e; Protein kinase C epsilon type; unnamed protein product
Gene Aliases: nPKC-epsilon; PKCE; PRKCE
UniProt ID: (Human) Q02156
Entrez Gene ID: (Human) 5581
nucleotide binding
actin monomer binding
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
calcium-independent protein kinase C activity
protein binding
ATP binding
enzyme activator activity
zinc ion binding
kinase activity
transferase activity
enzyme binding
receptor activator activity
ethanol binding
metal ion binding
14-3-3 protein binding
protein serine kinase activity
MAPK cascade
macrophage activation involved in immune response
immune system process
apoptotic process
cell adhesion
signal transduction
toxin catabolic process
positive regulation of epithelial cell migration
positive regulation of fibroblast migration
positive regulation of cell-substrate adhesion
regulation of metal ion transport
peptidyl-serine phosphorylation
regulation of lipid metabolic process
insulin secretion
positive regulation of actin filament polymerization
negative regulation of protein ubiquitination
cell-substrate adhesion
lipopolysaccharide-mediated signaling pathway
positive regulation of insulin secretion
positive regulation of synaptic transmission, GABAergic
positive regulation of cytokinesis
positive regulation of superoxide anion generation
intracellular signal transduction
locomotory exploration behavior
TRAM-dependent toll-like receptor 4 signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
xenobiotic catabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to morphine
positive regulation of MAPK cascade
positive regulation of lipid catabolic process
regulation of release of sequestered calcium ion into cytosol
cell division
establishment of localization in cell
synaptic transmission, GABAergic
regulation of insulin secretion involved in cellular response to glucose stimulus
mucus secretion
positive regulation of mucus secretion
cellular response to ethanol
cellular response to prostaglandin E stimulus
cellular response to hypoxia
positive regulation of wound healing
negative regulation of sodium ion transmembrane transport
positive regulation of protein localization to plasma membrane
regulation of cation transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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