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Invitrogen
NF1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-83777
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NF1. Recombinant protein control fragment (Product #RP-102980).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ALLVLRQLDS IDLWNPDAPG ETF
Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 91%.
Target Information
The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp686J1293; FLJ21220; neurofibromatosis 1; neurofibromatosis-related protein NF-1; unnamed protein product
Gene Aliases: NFNS; VRNF; WSS
UniProt ID: (Human) P21359
Entrez Gene ID: (Human) 4763
MAPK cascade
osteoblast differentiation
metanephros development
response to hypoxia
liver development
negative regulation of endothelial cell proliferation
regulation of cell-matrix adhesion
cell communication
Ras protein signal transduction
negative regulation of neuroblast proliferation
brain development
peripheral nervous system development
heart development
visual learning
Schwann cell development
spinal cord development
forebrain astrocyte development
cerebral cortex development
myelination in peripheral nervous system
actin cytoskeleton organization
extracellular matrix organization
collagen fibril organization
adrenal gland development
negative regulation of cell migration
wound healing
positive regulation of apoptotic process
negative regulation of MAPK cascade
pigmentation
protein kinase B signaling
positive regulation of neuron apoptotic process
regulation of blood vessel endothelial cell migration
positive regulation of GTPase activity
regulation of bone resorption
regulation of glial cell differentiation
regulation of angiogenesis
negative regulation of fibroblast proliferation
sympathetic nervous system development
camera-type eye morphogenesis
negative regulation of oligodendrocyte differentiation
smooth muscle tissue development
artery morphogenesis
forebrain morphogenesis
regulation of developmental process
cognition
regulation of intracellular signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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