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Invitrogen
HACE1 Polyclonal Antibody
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Product Details
PA5-83803
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HACE1. Recombinant protein control fragment (Product #RP-106106).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PVNENDILLV HRDSIFRSSC EVVSKANCAK LKQGIAVRFH GEEGMGQGVV REWFDILSNE IVNPDYALFT QSADGTT
Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 97%.
Target Information
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase HACE1; hace 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1
Gene Aliases: HACE1; KIAA1320; SPPRS
UniProt ID: (Human) Q8IYU2
Entrez Gene ID: (Human) 57531
transcription, DNA-templated
regulation of transcription, DNA-templated
Golgi organization
cell cycle
protein ubiquitination
Rac protein signal transduction
regulation of cell migration
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
membrane fusion
protein K48-linked ubiquitination
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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