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Invitrogen
SFPQ Polyclonal Antibody
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Product Details
PA5-83870
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SFPQ. Recombinant protein control fragment (Product #RP-104161).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IGYEANPGVP PATMSGSMMG SDMRTERFGQ GGAGPVGGQG PRGMGPGTPA GYGRGREEYE GPNK
Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 100 kDa DNA-pairing protein; DNA-binding p52/p100 complex, 100 kDa subunit; hPOMp100; polypyrimidine tract binding protein associated; polypyrimidine tract-binding protein-associated splicing factor; Polypyrimidine tract-binding protein-associated-splicing factor; protein phosphatase 1, regulatory subunit 140; PSF; PTB-associated splicing factor; PTB-associated-splicing factor; splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated); splicing factor proline/glutamine-rich; Splicing factor, proline- and glutamine-rich
Gene Aliases: POMP100; PPP1R140; PSF; SFPQ
UniProt ID: (Human) P23246
Entrez Gene ID: (Human) 6421
nucleotide binding
transcription regulatory region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
core promoter binding
chromatin binding
protein binding
histone deacetylase binding
transcription regulatory region DNA binding
poly(A) RNA binding
RNA metabolism protein
negative regulation of transcription from RNA polymerase II promoter
alternative mRNA splicing, via spliceosome
double-strand break repair via homologous recombination
transcription, DNA-templated
mRNA processing
RNA splicing
regulation of circadian rhythm
negative regulation of circadian rhythm
positive regulation of sister chromatid cohesion
negative regulation of transcription, DNA-templated
rhythmic process
histone H3 deacetylation
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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