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Invitrogen
Ku70 Polyclonal Antibody
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Product Details
PA5-83871
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human XRCC6. Recombinant protein control fragment (Product #RP-103007).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PPYFVALVPQ EEELDDQKIQ VTPPGFQLVF LPFADDKRKM PFTEKIMATP EQVGKMKAIV EKLRFTYRSD SFENPVLQQH FRNLEALALD LMEPEQAVDL
Highest antigen sequence indentity to the following orthologs: Rat - 87%, Mouse - 85%.
Target Information
XRCC6 is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CT; CTA-216E10.7; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; DNA repair protein Ku70; DNA repair protein XRCC6; G22P1; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; Ku protein subunit; Ku70; Lupus Ku autoantigen protein p70; OTTHUMP00000028581; p70 autoantigen; thyroid autoantigen; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); Thyroid-lupus autoantigen; thyroid-lupus autoantigen p70; TLAA; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 6; X-ray repair cross-complementing protein 6
Gene Aliases: CTC75; CTCBF; G22P1; KU70; ML8; TLAA; XRCC6
UniProt ID: (Human) P12956
Entrez Gene ID: (Human) 2547
nucleotide binding
transcription regulatory region sequence-specific DNA binding
DNA binding
DNA helicase activity
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
RNA binding
catalytic activity
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
hydrolase activity
lyase activity
ATPase activity
cyclin binding
telomeric DNA binding
macromolecular complex binding
DNA end binding
5'-deoxyribose-5-phosphate lyase activity
scaffold protein binding
telomere maintenance
recombinational repair
activation of innate immune response
immune system process
positive regulation of immune system process
DNA repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
response to ionizing radiation
negative regulation of macromolecule biosynthetic process
innate immune response
positive regulation of lymphocyte differentiation
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of smooth muscle cell proliferation
cellular hyperosmotic salinity response
cellular response to gamma radiation
cellular response to X-ray
double-strand break repair via classical nonhomologous end joining
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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