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Invitrogen
SLITRK3 Polyclonal Antibody
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Product Details
PA5-83892
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLITRK3. Recombinant protein control fragment (Product #RP-108201).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EEVAVSSAQE AGSAERGGPG TQPPGMGEAL LGSEQFAETP KENHSNYRTL LEKEKEWALA VSSSQLNTIV TVNHHHPHHP AVGGVSGVVG GTGGDLAGFR HHEKNGGVVL FPPGGGCGSG SMLLDRERPQ PAPCTVGFVD CLY
Highest antigen sequence indentity to the following orthologs: Mouse - 88%, Rat - 89%.
Target Information
SLIT and NTRK-like family 3 (Slitrk3) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the protein family. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk3 inhibited neurite outgrowth in cultured neurons, suggesting that these proteins are involved in the control of neurite outgrowth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SLIT and NTRK-like protein 3; slit and trk like gene 3; unnamed protein product
Gene Aliases: KIAA0848; SLITRK3
UniProt ID: (Human) O94933
Entrez Gene ID: (Human) 22865
axonogenesis
synaptic transmission, GABAergic
positive regulation of synapse assembly
terminal button organization
neurotransmitter-gated ion channel clustering
postsynaptic density assembly
gephyrin clustering involved in postsynaptic density assembly
synaptic membrane adhesion
regulation of presynapse assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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