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Invitrogen

CYLD Polyclonal Antibody

View all (16) CYLD antibodies

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CYLD Polyclonal Antibody

Product Details

PA5-83991

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CYLD. Recombinant protein control fragment (Product #RP-98337).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Amount

20 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2791143

Product Specific Information

Immunogen sequence: PPLEINSRVS LKVGETIESG TVIFCDVLPG KESLGYFVGV DMDNPIGNWD GRFDGVQLCS FACVESTILL HINDIIPESV TQER

Highest antigen sequence indentity to the following orthologs: Rat - 81%, Mouse - 95%.

Target Information

CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cyld; cylindromatosis (turban tumor syndrome); Deubiquitinating enzyme CYLD; FLJ20180; FLJ31664; FLJ78684; probable ubiquitin carboxyl-terminal hydrolase CYLD; Ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin specific peptidase like 2; Ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; Ubiquitin-specific-processing protease CYLD; unnamed protein product

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Gene Aliases: BRSS; CDMT; CYLD; CYLD1; CYLDI; EAC; FTDALS8; HSPC057; KIAA0849; MFT; MFT1; SBS; TEM; USPL2

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UniProt ID: (Human) Q9NQC7

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Entrez Gene ID: (Human) 1540

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Function(s)
thiol-dependent ubiquitin-specific protease activity protein binding peptidase activity cysteine-type peptidase activity zinc ion binding hydrolase activity protein kinase binding metal ion binding Lys63-specific deubiquitinase activity ubiquitinyl hydrolase activity, acting on linear ubiquitin proline-rich region binding Lys48-specific deubiquitinase activity
Process(es)
immune system process proteolysis I-kappaB kinase/NF-kappaB signaling regulation of mitotic cell cycle regulation of tumor necrosis factor-mediated signaling pathway Wnt signaling pathway protein deubiquitination negative regulation of NF-kappaB transcription factor activity negative regulation of type I interferon production nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling CD4-positive or CD8-positive, alpha-beta T cell lineage commitment innate immune response regulation of B cell differentiation positive regulation of T cell differentiation negative regulation of JNK cascade homeostasis of number of cells regulation of inflammatory response negative regulation of inflammatory response positive regulation of T cell receptor signaling pathway regulation of necroptotic process necroptotic process regulation of microtubule cytoskeleton organization protein K63-linked deubiquitination negative regulation of canonical Wnt signaling pathway ripoptosome assembly involved in necroptotic process negative regulation of NIK/NF-kappaB signaling regulation of cilium assembly negative regulation of p38MAPK cascade positive regulation of cellular protein localization protein linear deubiquitination negative regulation of interleukin-18-mediated signaling pathway positive regulation of extrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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