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Invitrogen
SF3B1 Polyclonal Antibody
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Product Details
PA5-83997
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SF3B1. Recombinant protein control fragment (Product #RP-101202).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LDSTGYYDQE IYGGSDSRFA GYVTSIAATE LEDDDDDYSS STSLLGQKKP GYHAPVALLN DIPQSTEQYD PFAEHRPPKI ADRED
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
Target Information
This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex. The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: pre-mRNA processing 10; pre-mRNA splicing factor SF3b, 155 kDa subunit; Pre-mRNA-splicing factor SF3b 155 kDa subunit; SAP 155; SF3b155; similar to Xenopus laevis 146 kDa nuclear protein with GenBank Accession Number Y08997; Spliceosome-associated protein 155; Splicing factor 3B subunit 1; splicing factor 3b, subunit 1, 155kDa; unnamed protein product
Gene Aliases: Hsh155; MDS; PRP10; PRPF10; SAP155; SF3B1; SF3b155
UniProt ID: (Human) O75533
Entrez Gene ID: (Human) 23451
spliceosomal complex assembly
RNA splicing, via transesterification reactions
mRNA splicing, via spliceosome
chromatin remodeling
mRNA processing
RNA splicing
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
U2-type prespliceosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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