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Invitrogen
KPNB1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-83998
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KPNB1. Recombinant protein control fragment (Product #RP-106271).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NVCWAFSSLA EAAYEAADVA DDQEEPATYC LSSSFELIVQ KLLETTDRPD GHQNNLRSSA YESLMEIVKN SAKDCYPAVQ KTTLVIMERL QQVLQMESHI QSTSDRIQFN DLQSLLCATL QNVLRK
Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.
Target Information
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:6400; importin 1; importin 90; importin beta-1 subunit; KapB1; karyopherin (importin) beta 1; karyopherin beta 1; MGC2155; MGC2156; MGC2157; nuclear factor p97; pore targeting complex 97 kDa subunit; PTAC97; unnamed protein product
Gene Aliases: IMB1; Impnb; IPO1; IPOB; NTF97
UniProt ID: (Human) Q14974
Entrez Gene ID: (Human) 3837
RNA import into nucleus
protein import into nucleus
NLS-bearing protein import into nucleus
ribosomal protein import into nucleus
intracellular protein transport
mitotic chromosome movement towards spindle pole
mitotic metaphase plate congression
astral microtubule organization
establishment of mitotic spindle localization
regulation of cholesterol biosynthetic process
positive regulation of cholesterol biosynthetic process
mitotic spindle assembly
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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