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Invitrogen
SUV420H2 Polyclonal Antibody
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Product Details
PA5-84109
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KMT5C. Recombinant protein control fragment (Product #RP-99077).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EGFFGEKNEH CECHTCERKG EGAFRTRPRE PALPPRPLDK YQLRETKRRL QQGLDSG
Highest antigen sequence indentity to the following orthologs: Mouse - 84%, Rat - 86%.
Target Information
SUV420H2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. The protein mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H4]-lysine20 N-methyltransferase KMT5B; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; Histone-lysine N-methyltransferase KMT5C; histone-lysine N-methyltransferase SUV420H2; lysine (K)-specific methyltransferase 5C; Lysine N-methyltransferase 5C; Lysine-specific methyltransferase 5C; Su(var)4-20 homolog 2; Suppressor of variegation 4-20 homolog 2; unnamed protein product
Gene Aliases: KMT5C; PP7130; Suv4-20h2; SUV420H2
UniProt ID: (Human) Q86Y97
Entrez Gene ID: (Human) 84787
chromatin binding
protein binding
methyltransferase activity
transferase activity
histone binding
histone methyltransferase activity (H4-K20 specific)
metal ion binding
histone H4 methyltransferase activity
histone H4K20me methyltransferase activity
histone H4K20 monomethyltransferase activity
S-adenosyl-L-methionine binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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