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Invitrogen
CaV1.1 Polyclonal Antibody
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Product Details
PA5-84312
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CACNA1S. Recombinant protein control fragment (Product #RP-99773).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EEEKSTMAKK LEQKPKGEGI PTTAKLKIDE FESNVNEVKD PYPSADFPGD DEEDEPEIPL SPRPRPLAEL
Highest antigen sequence indentity to the following orthologs: Rat - 96%, Mouse - 91%.
Target Information
Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling. The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; calcium channel, voltage-dependent, L type, alpha 1S subunit; Cav1.1 alpha-1; DHP; dihydropyridine receptor alpha 1 subunit; dihydropyridine-sensitive L-type calcium channel alpha-1 subunit; Voltage-dependent L-type calcium channel subunit alpha-1S; Voltage-gated calcium channel subunit alpha Cav1.1
Gene Aliases: CACH1; CACN1; CACNA1S; CACNL1A3; Cav1.1; CCHL1A3; CMYO18; CMYP18; DHPRM; HOKPP; HOKPP1; hypoPP; MHS5; TTPP1
UniProt ID: (Human) Q13698
Entrez Gene ID: (Human) 779
skeletal system development
extraocular skeletal muscle development
ion transport
calcium ion transport
muscle contraction
striated muscle contraction
endoplasmic reticulum organization
skeletal muscle tissue development
myoblast fusion
neuromuscular junction development
ion transmembrane transport
skeletal muscle adaptation
positive regulation of muscle contraction
skeletal muscle fiber development
release of sequestered calcium ion into cytosol
muscle cell development
transmembrane transport
calcium ion transmembrane transport
cellular response to caffeine
calcium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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