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Invitrogen
Desmoglein 3 Polyclonal Antibody
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FIGURE: 1 / 6
Desmoglein 3 Antibody (PA5-84316) in IHC (P)
Immunohistochemistry analysis of Desmoglein 3 in human endometrium, liver, skeletal muscle and tonsil. Samples were incubated with Desmoglein 3 polyclonal antibody (Product # PA5-84316). Shows similar protein distribution across tissues to independent Desmoglein 3 antibody (Product # PA5-83843) (B).
Product Details
PA5-84316
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DSG3. Recombinant protein control fragment (Product #
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Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FRPASKTFTV QKGISSKKLV DYILGTYQAI DEDTNKAASN VKYVMGRNDG GYLMIDSKTA EIKFVKNMNR DSTFIVNKTI TAEVLAIDEY TGKTSTGTVY VRVPDFND
Highest antigen sequence indentity to the following orthologs: Rat - 81%, Mouse - 80%.
Target Information
Desmoglein 3 (Dsg3), also known as Cadherin family member 6 (CDHF6), is a member of the desmosomal cadherin family and plays a critical role in cell-cell adhesion. It is predominately expressed in stratified squamous epithelium, including the skin, oral mucosa, and esophagus. Desmoglein 3 has been characterized as the auto-antigen of pemphigus vulgaris (PV), a life-threatening autoimmune disease. Binding of anti-Desmoglein 3 autoantibodies causes the loss of cell-cell adhesion, which clinically manifests as blisters on the skin and oral mucosa, and histologically as suprabasilar acantholysis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 130 kDa pemphigus vulgaris antigen; Cadherin family member 6; Desmoglein-3; DKFZp686P23184; PVA; unnamed protein product
Gene Aliases: ABOLM; CDHF6; DSG3; PVA
UniProt ID: (Human) P32926
Entrez Gene ID: (Human) 1830
desmosome assembly
actin filament organization
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
negative regulation of cell migration
regulation of protein stability
adherens junction assembly
cell-cell adhesion
tight junction assembly
positive regulation of bicellular tight junction assembly
negative regulation of p38MAPK cascade
positive regulation of protein localization to adherens junction
positive regulation of protein localization to membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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