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Invitrogen
ITGB1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-84409
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ITGB1. Recombinant protein control fragment (Product #RP-108215).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KANAKSCGEC IQAGPNCGWC TNSTFLQEGM PTSARCDDLE ALKKKGCPPD DIENPRGSKD IKKNKNVTNR SKGTAEKLKP EDITQIQPQQ LVLRLRSGEP
Highest antigen sequence indentity to the following orthologs: Mouse - 91%, Rat - 91%.
Target Information
CD29, also known as ITGB1 or Integrin Subunit Beta 1, is a 110 kDa cell surface glycoprotein widely expressed by various cells, including all leukocytes. It forms non-covalently linked heterodimers with at least six different alpha integrins (CD49a-f), creating VLA-1 through VLA-6 complexes, as well as with CD51. These alpha-beta integrin heterodimers mediate a range of cellular responses, including adhesion, trafficking, proliferation, and differentiation. CD29-containing integrins bind to extracellular matrix proteins such as collagen, laminin, fibronectin, and vitronectin. Some integrins also interact with cellular receptors like VCAM-1 and MadCAM-1. CD29 plays a crucial role in immune cell trafficking from blood to tissue, particularly during leukocyte emigration and extravascular migration. It is involved in regulating tissue damage and disease symptoms related to inflammatory bowel disease. In the presence of anti-tumor drugs, decreased expression of ITGB1 correlates with multidrug resistance in tumor cells. ITGB1-dependent mechanisms enhance cytokine secretion in human airway smooth muscle in response to IL-1beta, facilitated by fibronectin and type I collagen. More than eight beta subunits with numerous splice variant isoforms have been identified in mammals, including two major forms: beta1A and beta1D. Beta1A is present in all tissues except cardiac and skeletal muscle, which express the beta1D variant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glycoprotein IIa; integrin beta 1; integrin beta-1 subunit (cytoplasmic domain); Integrin beta1; integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12); ITBG1D; unnamed protein product; very late activation protein, beta polypeptide
Gene Aliases: CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB
UniProt ID: (Human) P05556
Entrez Gene ID: (Human) 3688
magnesium ion binding
fibronectin binding
protease binding
actin binding
obsolete cell adhesion receptor activity
integrin binding
calcium ion binding
protein binding
coreceptor activity
protein kinase binding
C-X3-C chemokine binding
signaling receptor activity
laminin binding
macromolecular complex binding
cadherin binding
protein heterodimerization activity
cell adhesion molecule binding
collagen binding involved in cell-matrix adhesion
integrin binding involved in cell-matrix adhesion
protein tyrosine kinase binding
establishment of mitotic spindle orientation
angiogenesis
phagocytosis
cellular defense response
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
leukocyte cell-cell adhesion
cell-matrix adhesion
calcium-independent cell-matrix adhesion
transforming growth factor beta receptor signaling pathway
integrin-mediated signaling pathway
myoblast fusion
regulation of collagen catabolic process
positive regulation of fibroblast migration
response to muscle activity
cell migration
CD40 signaling pathway
cell projection organization
lamellipodium assembly
B cell differentiation
extracellular matrix organization
positive regulation of cell migration
cell-substrate adhesion
receptor internalization
cell adhesion mediated by integrin
cell-cell adhesion mediated by integrin
heterotypic cell-cell adhesion
wound healing, spreading of epidermal cells
maintenance of blood-brain barrier
positive regulation of apoptotic process
stress fiber assembly
positive regulation of GTPase activity
myoblast differentiation
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of angiogenesis
negative regulation of vasoconstriction
mesodermal cell differentiation
regulation of developmental process
modulation of synaptic transmission
leukocyte tethering or rolling
positive regulation of protein kinase B signaling
positive regulation of glutamate uptake involved in transmission of nerve impulse
cellular response to low-density lipoprotein particle stimulus
basement membrane organization
positive regulation of wound healing
cell-cell adhesion
regulation of spontaneous synaptic transmission
reactive gliosis
positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of protein localization to plasma membrane
regulation of synapse pruning
negative regulation of anoikis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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