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Invitrogen
Thrombospondin 1 Polyclonal Antibody
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Product Details
PA5-84435
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human THBS1. Recombinant protein control fragment (Product #RP-106964).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LTLDNNVVNG SSPAIRTNYI GHKTKDLQAI CGISCDELSS MVLELRGLRT IVTTLQDSIR KVTEENKELA NELRRPPLCY HNGVQYRNNE EWTVDSCTEC HCQNSVTICK KVSCPIMPCS NATVPDGECC PRC
Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 94%.
Target Information
Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycoprotein G; Thrombospondin; Thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1; unnamed protein product
Gene Aliases: THBS; THBS-1; THBS1; TSP; TSP-1; TSP1
UniProt ID: (Human) P07996
Entrez Gene ID: (Human) 7057
phosphatidylserine binding
fibronectin binding
protease binding
endopeptidase inhibitor activity
integrin binding
extracellular matrix structural constituent
calcium ion binding
protein binding
heparin binding
fibroblast growth factor binding
low-density lipoprotein particle binding
protein homodimerization activity
laminin binding
proteoglycan binding
transforming growth factor beta binding
extracellular matrix binding
fibrinogen binding
collagen V binding
angiogenesis
response to hypoxia
negative regulation of endothelial cell proliferation
negative regulation of cell-matrix adhesion
sprouting angiogenesis
chronic inflammatory response
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
negative regulation of dendritic cell antigen processing and presentation
positive regulation of immune system process
apoptotic process
inflammatory response
immune response
response to unfolded protein
cell adhesion
positive regulation of cell proliferation
negative regulation of cell proliferation
response to xenobiotic stimulus
response to mechanical stimulus
response to glucose
positive regulation of endothelial cell migration
negative regulation of endothelial cell migration
negative regulation of plasma membrane long-chain fatty acid transport
negative regulation of nitric oxide mediated signal transduction
negative regulation of cGMP-mediated signaling
negative regulation of plasminogen activation
positive regulation of macrophage chemotaxis
positive regulation of fibroblast migration
regulation of cell-substrate adhesion
cell migration
negative regulation of angiogenesis
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
response to magnesium ion
response to progesterone
negative regulation of interleukin-10 production
negative regulation of interleukin-12 production
negative regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor production
positive regulation of transforming growth factor beta1 production
response to testosterone
cellular response to heat
response to endoplasmic reticulum stress
nitric oxide-cGMP-mediated signaling pathway
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of phosphorylation
positive regulation of macrophage activation
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
engulfment of apoptotic cell
positive regulation of translation
positive regulation of angiogenesis
behavioral response to pain
blood vessel morphogenesis
positive regulation of smooth muscle cell proliferation
positive regulation of chemotaxis
response to calcium ion
negative regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of fibrinolysis
cellular response to tumor necrosis factor
cellular response to growth factor stimulus
positive regulation of transforming growth factor beta production
blood coagulation, fibrin clot formation
negative regulation of cell migration involved in sprouting angiogenesis
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
negative regulation of sprouting angiogenesis
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
negative regulation of endothelial cell chemotaxis
negative regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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