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Invitrogen
EED Polyclonal Antibody
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Product Details
PA5-84440
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human EED. Recombinant protein control fragment (Product #RP-105148).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SDENSNPDLS GDENDDAVSI ESGTNTERPD TPTNTPNAPG RKSWGKGKWK SKKCKYSFKC VNSLKEDHNQ PLFGVQFNWH SKEGDPL
Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
The EED protein (WAIT-1 or WD protein associated with integrin cytoplasmic tails-1), also called embryonic ectoderm development, is a member of the superfamily of WD-40 repeat proteins and widely conserved polycomb group (PcG) family of proteins. The polycomb group (PcG) is a large and evolutionarily conserved set of genes whose products act in multimeric complexes to modify histones, which are then thought to cause stable and heritable states of transcriptional repression. EED shuttles between the nucleus and the plasma membrane and can interact with the cytoplasmic tail of integrin Beta-7 subunit. EED exerted an antiviral activity at the late stage of HIV-1 replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Embryonic ectoderm development protein; hEED; Polycomb protein EED; WAIT-1; WD protein associating with integrin cytoplasmic tails 1
Gene Aliases: EED; HEED; WAIT1
UniProt ID: (Human) O75530
Entrez Gene ID: (Human) 8726
negative regulation of transcription from RNA polymerase II promoter
regulation of gene expression by genetic imprinting
transcription, DNA-templated
histone methylation
spinal cord development
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of histone H3-K27 methylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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