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Invitrogen
GPAM Polyclonal Antibody
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Product Details
PA5-84441
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GPAM. Recombinant protein control fragment (Product #RP-105149).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DILIIPVGIS YDRIIEGHYN GEQLGKPKKN ESLWSVARGV IRMLRKNYGC VRVDFAQPFS LKEYLESQSQ KPVSALLSLE QALLPAILPS RPSDAADEG
Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 93%.
Target Information
Glycerol-3-phosphate acyltransferase 1 (GPAT1), one of four known GPAT isoforms, is located on the mitochondrial outer membrane, allowing reciprocal regulation with carnitine palmitoyltransferase-1. It is thought to be critical for the development of hepatic steatosis; steatosis triggered by GPAT1 overexpression leads to hepatic and possibly peripheral insulin resistance. GPAT1 is transcriptionally upregulated by insulin and sterol regulatory element binding protein (SREBP-1) and downregulated by AMP-activated protein kinase. Mice deficient in GPAT1 exhibit decreased triacylglycerol (TAG) in cardiomyocytes even in high-fat diets, suggesting that GPAT1 contributes significantly to TAG accumulation in heart tissue during lipogenic or high fat diets. At least two isoforms of GPAT1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT-1; RP11-426E5.2; unnamed protein product
Gene Aliases: GPAM; GPAT; GPAT1; KIAA1560
UniProt ID: (Human) Q9HCL2
Entrez Gene ID: (Human) 57678
regulation of cytokine production
lipid metabolic process
fatty acid metabolic process
acyl-CoA metabolic process
triglyceride metabolic process
glycerophospholipid metabolic process
diacylglycerol biosynthetic process
phosphatidic acid biosynthetic process
phosphatidylglycerol biosynthetic process
activation-induced cell death of T cells
phospholipid biosynthetic process
response to glucose
CDP-diacylglycerol biosynthetic process
triglyceride biosynthetic process
positive regulation of multicellular organism growth
positive regulation of activated T cell proliferation
activated T cell proliferation
defense response to virus
fatty acid homeostasis
phospholipid homeostasis
negative regulation of activation-induced cell death of T cells
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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