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Invitrogen
DHCR24 Polyclonal Antibody
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Product Details
PA5-84579
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human DHCR24. Recombinant protein control fragment (Product #RP-103483).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ILEVDTKKQI VRVEPLVTMG QVTALLTSIG WTLPVLPELD DLTVGGLIMG TGIESSSHKY GLFQHICTAY ELVLADGSFV RCTPSENSDL FYAVPWSCGT LGFLVAAEIR IIPAKKYVKL RFEPVRGLEA ICAKFTHESQ
Highest antigen sequence indentity to the following orthologs: Rat - 97%, Mouse - 96%.
Target Information
DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of its gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 24-dehydrocholesterol reductase; 3 beta-hydroxysterol delta 24-reductase; 3-beta-hydroxysterol Delta-24-reductase; Delta(24)-sterol reductase; desmosterol-to-cholesterol enzyme; Diminuto/dwarf1 homolog; seladin 1; Seladin-1; selective AD indicator 1
Gene Aliases: DCE; DHCR24; KIAA0018; Nbla03646; seladin-1; SELADIN1
UniProt ID: (Human) Q15392
Entrez Gene ID: (Human) 1718
delta24(24-1) sterol reductase activity
oxidoreductase activity, acting on CH-OH group of donors
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
enzyme binding
peptide antigen binding
delta24-sterol reductase activity
flavin adenine dinucleotide binding
reductase
cholesterol biosynthetic process
apoptotic process
response to oxidative stress
cell cycle arrest
Ras protein signal transduction
protein localization
negative regulation of cell proliferation
response to hormone
tissue development
male genitalia development
plasminogen activation
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process via lathosterol
amyloid precursor protein catabolic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
skin development
oxidation-reduction process
membrane organization
regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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