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Invitrogen

CDK5 Polyclonal Antibody

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CDK5 Polyclonal Antibody

Product Details

PA5-84646

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human CDK5. Recombinant protein control fragment (Product #RP-107340).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2791797

Product Specific Information

Immunogen sequence: TEEQWPSMTK LPDYKPYPMY PATTSLVNVV PKLNATGRDL LQNLLKCNPV QRISAEEALQ HPYFSDFCP

Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.

Target Information

CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CDK5; CDK5 activator 1; CDK5-SV; Cell division protein kinase 5; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; epididymis secretory sperm binding protein; protein kinase CDK5 splicing; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit

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Gene Aliases: CDK5; CDKN5; LIS7; PSSALRE

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UniProt ID: (Human) Q00535

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Entrez Gene ID: (Human) 1020

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Function(s)
nucleotide binding p53 binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding microtubule binding kinase activity transferase activity receptor inhibitor activity acetylcholine receptor activator activity ionotropic glutamate receptor binding ErbB-3 class receptor binding tau protein binding tau-protein kinase activity Hsp90 protein binding protein serine kinase activity
Process(es)
microtubule cytoskeleton organization neuron migration synaptic transmission, dopaminergic intracellular protein transport apoptotic process cell-matrix adhesion chemical synaptic transmission nervous system development axonogenesis synapse assembly skeletal muscle tissue development motor neuron axon guidance associative learning visual learning Schwann cell development synaptic vesicle exocytosis regulation of macroautophagy cell migration sensory perception of pain telencephalon development cerebellum development cerebellar cortex development cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development cerebral cortex development corpus callosum development actin cytoskeleton organization neuron differentiation regulation of cell migration negative regulation of axon extension forebrain development neuron projection development negative regulation of protein ubiquitination negative regulation of synaptic plasticity receptor catabolic process synaptic transmission, glutamatergic protein localization to synapse response to cocaine regulation of apoptotic process receptor clustering positive regulation of neuron apoptotic process negative regulation of cell cycle negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis negative regulation of protein export from nucleus behavioral response to cocaine regulation of synaptic plasticity synaptic vesicle endocytosis synaptic vesicle transport rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis cell division neuron apoptotic process establishment of localization in cell regulation of cell cycle regulation of synaptic transmission, glutamatergic regulation of postsynaptic membrane potential excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import positive regulation of protein targeting to membrane positive regulation of presynaptic cytosolic calcium concentration regulation of cell cycle phase transition regulation of protein localization to plasma membrane negative regulation of calcium ion-dependent exocytosis of neurotransmitter regulation of synaptic vesicle recycling cellular response to beta-amyloid
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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