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Invitrogen
Munc13-4 Polyclonal Antibody
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Product Details
PA5-84746
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human UNC13D. Recombinant protein control fragment (Product #RP-105417).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SFHLDMWDLD TVESVRQKLG ELTDLHGLRR IFKEARKDKG QDDFLGNVVL RLQDLRCRED QWYPLEPRTE TYPDRGQCHL QFQLIHKRRA TSASRSQPSY TVHLHLLQQL VSHEVTQHEA GSTSWDGSLS PQAATVLFLH ATQKDLSD
Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 92%.
Target Information
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: munc 13-4; Munc13-4; Protein unc-13 homolog D; unnamed protein product
Gene Aliases: FHL3; HLH3; HPLH3; Munc13-4; UNC13D
UniProt ID: (Human) Q70J99
Entrez Gene ID: (Human) 201294
granuloma formation
germinal center formation
exocytosis
phagocytosis
regulation of mast cell degranulation
natural killer cell degranulation
positive regulation of exocytosis
secretion
defense response to virus
establishment of localization in cell
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of regulated secretory pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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