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Invitrogen
MARCKS Polyclonal Antibody
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Product Details
PA5-84764
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MARCKS. Recombinant protein control fragment (Product #RP-106359).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DPQEAKPQEA AVAPEKPPAS DETKAAEEPS KVEEK
Highest antigen sequence indentity to the following orthologs: Rat - 46%, Mouse - 46%.
Target Information
MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 80K-L protein; FLJ14368; FLJ90045; MARCKS; MARCS; Myristoylated alanine-rich C-kinase substrate; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); phosphomyristin; Protein kinase C substrate, 80 kDa protein, light chain
Gene Aliases: 80K-L; MACS; MARCKS; PKCSL; PRKCSL
UniProt ID: (Human) P29966
Entrez Gene ID: (Human) 4082
ventricular cardiac muscle tissue development
intracellular protein transport
actin filament organization
brain development
activation of phospholipase D activity
cell-substrate adhesion
regulation of insulin secretion
positive regulation of dendritic spine morphogenesis
positive regulation of protein kinase C activity
positive regulation of glucose import in response to insulin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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