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Invitrogen
AKR1C1 Polyclonal Antibody
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Product Details
PA5-84776
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human AKR1C1. Recombinant protein control fragment (Product #RP-105445).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EPWVDPNSPV LLEDPVLCAL AKKHK
Highest antigen sequence indentity to the following orthologs: Mouse - 72%, Rat - 72%.
Target Information
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20alpha-hydroxysteroid dehydrogenase; 3beta-hydroxysteroid 3-dehydrogenase; aldo-keto reductase C; Aldo-keto reductase family 1 member C1; chlordecone reductase homolog; Chlordecone reductase homolog HAKRC; DD1; Dihydrodiol dehydrogenase 1; dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; HBAB; hepatic dihydrodiol dehydrogenase; High-affinity hepatic bile acid-binding protein; indanol dehydrogenase; oxidoreductase; RP11-69D4.1; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase; unnamed protein product
Gene Aliases: 2-ALPHA-HSD; 20-ALPHA-HSD; AKR1C1; C9; DD1; DD1/DD2; DDH; DDH1; H-37; HAKRC; HBAB; MBAB
UniProt ID: (Human) Q04828
Entrez Gene ID: (Human) 1645
alditol:NADP+ 1-oxidoreductase activity
estradiol 17-beta-dehydrogenase activity
protein binding
alcohol dehydrogenase (NADP+) activity
oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
testosterone dehydrogenase [NAD(P)] activity
carboxylic acid binding
bile acid binding
3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
androsterone dehydrogenase activity
5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
androstan-3-alpha,17-beta-diol dehydrogenase activity
testosterone 17-beta-dehydrogenase (NADP+) activity
ketosteroid monooxygenase activity
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
indanol dehydrogenase activity
3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity
retinoid metabolic process
alcohol metabolic process
lipid metabolic process
prostaglandin metabolic process
xenobiotic metabolic process
digestion
steroid metabolic process
bile acid metabolic process
bile acid and bile salt transport
intestinal cholesterol absorption
epithelial cell differentiation
monocarboxylic acid metabolic process
hormone metabolic process
progesterone metabolic process
retinal metabolic process
cholesterol homeostasis
daunorubicin metabolic process
doxorubicin metabolic process
cellular response to jasmonic acid stimulus
positive regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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