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Invitrogen
SLC8A1 Polyclonal Antibody
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Product Details
PA5-84833
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SLC8A1. Recombinant protein control fragment (Product #RP-107729).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RHAADQARKA VSMHEVNTEV TENDPVSKIF FEQGTYQCLE
Highest antigen sequence indentity to the following orthologs: Rat - 90%, Mouse - 93%.
Target Information
Ca2+ plays a critical role in intracellular signaling and thus regulation of calcium balance is critical for the maintenance of this signaling function. The plasma membrane Na+/Ca2+ (NaCX) exchangers mediate Na+-dependent Ca2+ efflux in a wide variety of cell types. NaCX can move Ca2+ either into or out of cells, depending on the net Na+, Ca2+, and K+ gradient across the membrane. In mammals, at least 5 distinct genes code for the exchangers: Three NaCX (NaCX-1, NaCX-2, and NaCX-3), and two in the NaCKX family (NaCKX-1 and NaCKX-2). NaCX-1 is most prominently expressed in the heart where it plays a major role in excitation-contraction coupling (Matsuoka et al., 1993). NACX-1 may also be a target for protection of the heart and brain from ischemia and reperfusion injury (Hagihara et al., 2005; Bano et al., 2005; Choi, 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Na(+)/Ca(2+)-exchange protein 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; Sodium/calcium exchanger 1; solute carrier family 8 (sodium/calcium exchanger), member 1; Solute carrier family 8 member 1
Gene Aliases: CNC; NCX1; SLC8A1
UniProt ID: (Human) P32418
Entrez Gene ID: (Human) 6546
regulation of the force of heart contraction
regulation of heart rate
regulation of sodium ion transport
ion transport
cellular sodium ion homeostasis
muscle contraction
response to nutrient
response to glucose
regulation of cell communication by electrical coupling
positive regulation of fibroblast migration
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cardiac muscle contraction by calcium ion signaling
vascular smooth muscle contraction
telencephalon development
positive regulation of bone mineralization
response to ATP
cellular response to reactive oxygen species
sodium ion transmembrane transport
response to immobilization stress
response to muscle stretch
response to drug
response to hydrogen peroxide
relaxation of smooth muscle
negative regulation of cytosolic calcium ion concentration
cardiac muscle cell development
calcium ion homeostasis
relaxation of cardiac muscle
cardiac muscle contraction
cytosolic calcium ion transport
calcium ion transport into cytosol
calcium ion import
calcium ion transmembrane transport
cellular response to caffeine
cellular response to cAMP
sodium ion export
cellular response to hypoxia
membrane depolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
sodium ion import
positive regulation of the force of heart contraction
calcium ion export
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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