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Invitrogen
NEIL2 Polyclonal Antibody
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Product Details
PA5-84942
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NEIL2. Recombinant protein control fragment (Product #RP-105313).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IHPLSLGSVL SASRREVLVD HVVEFSTAWL QGKFQGRPQH TQVYQKEQCP AGHQVMKEAF GPEDGLQRLT WWCPQCQPQL SEEPEQCQFS
Highest antigen sequence indentity to the following orthologs: Mouse - 74%, Rat - 76%.
Target Information
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Endonuclease 8-like 2; Endonuclease VIII-like 2; NEH2; nei endonuclease VIII-like 2; Nei homolog 2; Nei-like protein 2; unnamed protein product
Gene Aliases: NEH2; NEI2; NEIL2
UniProt ID: (Human) Q969S2
Entrez Gene ID: (Human) 252969
nucleic acid binding
DNA binding
damaged DNA binding
catalytic activity
DNA-(apurinic or apyrimidinic site) lyase activity
protein binding
microtubule binding
zinc ion binding
hydrolase activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
lyase activity
DNA N-glycosylase activity
metal ion binding
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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