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Invitrogen
RASIP1 Polyclonal Antibody
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Product Details
PA5-85026
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RASIP1. Recombinant protein control fragment (Product #RP-108677).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CNDLELCDEA MALLDEVIMC TFQQSVYYLT KTLYSTLPAL LDSNPFTAGA ELPGPGAELG AMPPGLRP
Highest antigen sequence indentity to the following orthologs: Mouse - 97%, Rat - 97%.
Target Information
Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated transformation. Negative regulator of amino acid starvation-induced autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RAIN; Ras-interacting protein 1; unnamed protein product
Gene Aliases: RAIN; RASIP1
UniProt ID: (Human) Q5U651
Entrez Gene ID: (Human) 54922
angiogenesis
vasculogenesis
signal transduction
negative regulation of autophagy
positive regulation of integrin activation
negative regulation of Rho protein signal transduction
regulation of GTPase activity
branching morphogenesis of an epithelial tube
negative regulation of membrane permeability
negative regulation of Rho-dependent protein serine/threonine kinase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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