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Invitrogen
Kir4.1 (KCNJ10) Polyclonal Antibody
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Product Details
PA5-85057
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human KCNJ10. Recombinant protein control fragment (Product #RP-108298).
Conjugate
Form
Liquid
Concentration
0.30 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EFTPAISLSA SGKYIADFSL FDQVVKVASP SGLRDSTVRY GDPEKLKLEE SLREQAEKEG SALSVRISNV
Highest antigen sequence indentity to the following orthologs: Mouse - 100%, Rat - 97%.
Target Information
The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Downs syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent inwardly rectifying potassium channel Kir4.1; ATP-sensitive inward rectifier potassium channel 10; BIRK10; glial ATP-dependent inwardly rectifying potassium channel KIR4.1; Inward rectifier K(+) channel Kir1.2; inward rectifier K+ channel KIR1.2; KCNJ13 PEN; Potassium channel, inwardly rectifying subfamily J member 10; potassium voltage-gated channel subfamily J member 10; unnamed protein product
Gene Aliases: BIRK-10; KCNJ10; KCNJ13-PEN; KIR1.2; KIR4.1; SESAME
UniProt ID: (Human) P78508
Entrez Gene ID: (Human) 3766
ion transport
potassium ion transport
visual perception
adult walking behavior
oligodendrocyte development
central nervous system myelination
metal ion transport
ion transmembrane transport
regulation of ion transmembrane transport
cellular response to potassium ion
regulation of membrane potential
regulation of long-term neuronal synaptic plasticity
establishment of localization in cell
glutamate reuptake
potassium ion homeostasis
regulation of resting membrane potential
potassium ion transmembrane transport
non-motile cilium assembly
potassium ion import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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