Immunohistochemistry analysis of TBR1 in human cerebral cortex, liver, pancreas and skeletal muscle. Samples were incubated with TBR1 polyclonal antibody (Product # PA5-85066). Shows similar protein distribution across tissues to independent TBR1 antibody (Product # PA5-85065) (B).

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TBR1 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of TBR1 demonstrates antibody specificity. Immunohistochemical analysis of TBR1 using anti-TBR1 Polyclonal Antibody (Product #PA5-85066), shows significant staining of TBR1 in cerebral cortex and shows minimal or weak staining in kidney tissues. The relative expression levels of TBR1 within each tissue is shown using RNA-Seq. {RE}

Immunogen image

Immunogen Image TBR1 Polyclonal Antibody

Product Details

PA5-85066

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TBR1. Recombinant protein control fragment (Product #RP-108301).

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2792215

Product Specific Information

Immunogen sequence: LLSQSSQPQS AATAPSAMFP YPGQHGPAHP AFSIGSPSRY MAHHPVITNG AYNSLLSNSS PQGYPTAGYP YPQQYG

Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 100%.

Target Information

This gene is a member of a conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similar protein has been disrupted in mice and shown to be critical for early cortical development, and causes loss of projection neurons in the olfactory bulbs and olfactory cortex. The C-terminal region this similar protein was found to be necessary and sufficient for association with the guanylate kinase domain of calcium/calmodulin-dependent serine protein kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: T-box brain protein 1; T-box, brain 1; T-brain-1; TES-56; unnamed protein product

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Gene Aliases: AUTS5; IDDAS; TBR-1; TBR1; TES-56

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UniProt ID: (Human) Q16650

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Entrez Gene ID: (Human) 10716

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein kinase binding chromatin DNA binding

Process(es)

conditioned taste aversion cell fate specification chromatin remodeling regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter brain development specification of organ identity gene expression regulation of gene expression regulation of neuron projection development amygdala development commitment of neuronal cell to specific neuron type in forebrain cerebral cortex development neuron differentiation hindbrain development negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of axon guidance

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TBR1 Polyclonal Antibody

TBR1 Antibody (PA5-85066) in IHC (P)

Product Details

PA5-85066

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Amount

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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