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Invitrogen

IL-10 Polyclonal Antibody

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View all (99) IL-10 antibodies

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IL-10 Polyclonal Antibody

Product Details

PA5-95561

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
View 1 publication 1 publication

ELISA (ELISA)

0.1-0.5 µg/mL
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human IL10 recombinant protein (Position: S19-N178).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807363

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human U-87MG whole cell, rat testis tissue, mouse testis tissue, mouse SP20 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CSIF; Cytokine synthesis inhibitory factor; H-IL-10; il 10; IL-10; IL10; ILN; Interleukin; Interleukin-10; Interleukin10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor

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Gene Aliases: CSIF; GVHDS; IL-10; IL10; IL10A; IL10X; TGIF

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UniProt ID: (Human) P22301, (Mouse) P18893, (Rat) P29456

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Entrez Gene ID: (Human) 3586, (Mouse) 16153, (Rat) 25325

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Function(s)
cytokine activity interleukin-10 receptor binding protein binding growth factor activity protein dimerization activity
Process(es)
negative regulation of cytokine production response to molecule of bacterial origin negative regulation of cytokine secretion involved in immune response negative regulation of chronic inflammatory response to antigenic stimulus positive regulation of B cell apoptotic process inflammatory response immune response regulation of gene expression negative regulation of myeloid dendritic cell activation negative regulation of B cell proliferation negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production receptor biosynthetic process negative regulation of tumor necrosis factor biosynthetic process defense response to bacterium defense response to protozoan negative regulation of apoptotic process negative regulation of growth of symbiont in host negative regulation of nitric oxide biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade positive regulation of cytokine secretion negative regulation of inflammatory response negative regulation of membrane protein ectodomain proteolysis positive regulation of sequence-specific DNA binding transcription factor activity response to glucocorticoid regulation of sensory perception of pain negative regulation of cytokine activity branching involved in labyrinthine layer morphogenesis cellular response to lipopolysaccharide positive regulation of cytokine production positive regulation of endothelial cell proliferation chronic inflammatory response to antigenic stimulus positive regulation of immunoglobulin production negative regulation of cytokine production involved in immune response negative regulation of cell proliferation response to xenobiotic stimulus negative regulation of autophagy response to activity response to inactivity hemopoiesis B cell differentiation leukocyte chemotaxis response to lipopolysaccharide negative regulation of interferon-alpha production negative regulation of interleukin-1 production negative regulation of interleukin-18 production negative regulation of interleukin-8 production response to insulin negative regulation of heterotypic cell-cell adhesion positive regulation of heterotypic cell-cell adhesion response to carbon monoxide cellular response to hepatocyte growth factor stimulus type 2 immune response B cell proliferation negative regulation of T cell proliferation positive regulation of macrophage activation negative regulation of neuron apoptotic process regulation of isotype switching negative regulation of MHC class II biosynthetic process positive regulation of cell cycle negative regulation of mitotic cell cycle regulation of synapse organization cellular response to estradiol stimulus negative regulation of chemokine (C-C motif) ligand 5 production endothelial cell apoptotic process liver regeneration interleukin-10-mediated signaling pathway positive regulation of plasma cell differentiation positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of response to wounding negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of complement-dependent cytotoxicity positive regulation of sprouting angiogenesis negative regulation of vascular smooth muscle cell proliferation positive regulation of vascular smooth muscle cell proliferation negative regulation of endothelial cell apoptotic process aging response to organic substance response to drug
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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