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Invitrogen
DDRGK1 Polyclonal Antibody
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Product Details
PA5-100467
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DDRGK1(Accession Q96HY6), corresponding to amino acid residues P35-W85.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total DDRGK1.
Target Information
Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. May also play a role in the cellular response to endoplasmic reticulum stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dashurin; DDRGK domain-containing protein 1; UFM1-binding and PCI domain-containing protein 1; UFM1-binding protein 1 containing a PCI domain
Gene Aliases: 1110001I20Rik; 2600009E05Rik; AI326138; C20orf116; DDRGK1; dJ1187M17.3; SEMDSH; UFBP1
UniProt ID: (Human) Q96HY6, (Mouse) Q80WW9
Entrez Gene ID: (Human) 65992, (Mouse) 77006
blood circulation
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell migration
regulation of protein stability
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
ribosome disassembly
regulation of intracellular estrogen receptor signaling pathway
response to endoplasmic reticulum stress
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NF-kappaB transcription factor activity
cartilage development
reticulophagy
protein localization to endoplasmic reticulum
protein ufmylation
rescue of stalled ribosome
positive regulation of reticulophagy
positive regulation of plasma cell differentiation
positive regulation of proteasomal protein catabolic process
positive regulation of cell cycle G1/S phase transition
positive regulation of proteolysis involved in cellular protein catabolic process
positive regulation of I-kappaB phosphorylation
negative regulation of IRE1-mediated unfolded protein response
negative regulation of PERK-mediated unfolded protein response
positive regulation of protein localization to endoplasmic reticulum
protein K69-linked ufmylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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