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Invitrogen
ABCB7 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-101445
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ABCB7(Accession O75027), corresponding to amino acid residues F77-Y127.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ABCB7.
Target Information
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been implicated in X-linked sideroblastic anemia with ataxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter 7 protein; ATM1p; ATP-binding cassette 7; ATP-binding cassette sub-family B (MDR/TAP) member 7 isoform ABCB7_1; ATP-binding cassette sub-family B (MDR/TAP) member 7 isoform ABCB7_3; ATP-binding cassette sub-family B (MDR/TAP) member 7 isoform ABCB7_4; ATP-binding cassette sub-family B (MDR/TAP) member 7 isoform ABCB7_5; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7; ATP-binding cassette, sub-family B (MDR/TAP), member 7; unnamed protein product
Gene Aliases: ABC7; ASAT; Atm1p; EST140535
UniProt ID: (Human) O75027, (Mouse) Q61102
Entrez Gene ID: (Human) 22, (Mouse) 11306
heme biosynthetic process
cellular iron ion homeostasis
heme transport
iron-sulfur cluster assembly
iron ion transmembrane transport
transmembrane transport
positive regulation of heme biosynthetic process
iron-sulfur cluster export from the mitochondrion
positive regulation of iron-sulfur cluster assembly
negative regulation of reactive oxygen species biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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