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Invitrogen
NRL Polyclonal Antibody
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Product Details
PA5-101705
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NRL(Accession P54845), corresponding to amino acid residues M1-P49.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NRL.
Target Information
Nrl (neural retina leucine zipper) is a member of the Maf family of transcription factors, which characteristically contain a highly conserved basic leucine zipper (bZIP)-DNA binding motif. Both Nrl and c-Maf preferentially bind to T-MARE sites and are implicated in a wide variety of developmental and physiologic roles. The Maf-Nrl subfamily regulates the expression of cell type-specific genes in tissues of the hematopoietic system, cerebellum and developing hindbrain. Maf and Nrl proteins bind an extended AP-1-like sequence and can form heterodimers with Fos and Jun transcription factors. In retinal cells and photoreceptor cells, Nrl promotes the expression of rhodopsin through binding to the Nrl response element present in the rhodopsin promoter. Nrl is expressed throughout the developing central and peripheral nervous system during neuronal differentiation, and its expression is restricted to neocortex, brainstem and retinal neurons during adulthood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Maf-family bZIP transcription factor NRL; Neural retina-specific leucine zipper protein; neural retinal-specific leucine zipper; NRL; The gene is named NRL because it is expressed in neural retina andencodes a putative protein with a leucine zipper. Sequence similarity withv-maf oncogene [AAFVMAF].; unnamed protein product
Gene Aliases: D14H14S46E; D14S46E; NRL; NRL-MAF; RP27
UniProt ID: (Human) P54845, (Mouse) P54846
Entrez Gene ID: (Human) 4901, (Mouse) 18185
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
leucine zipper domain binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
sequence-specific DNA binding
basic leucine zipper transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
visual perception
positive regulation of gene expression
positive regulation of transcription from RNA polymerase II promoter
retinal rod cell development
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
regulation of rhodopsin gene expression
positive regulation of rhodopsin gene expression
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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