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Invitrogen

CYP11A1 Polyclonal Antibody

View all (10) CYP11A1 antibodies

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CYP11A1 Polyclonal Antibody

Product Details

PA5-102466

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CYP11A1(Accession P05108), corresponding to amino acid residues A411-Q461.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2851868

Product Specific Information

Antibody detects endogenous levels of total Cytochrome P450 11A1.

Target Information

CYP11A1, also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under the modulation of cAMP signal. CYP11A1 in steroidogenic cells converts cholesterol to pregnenolone, which is determined by hormonal control of cholesterol availability. Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site in the CYP11A1 gene is required for hormonal stimulation. c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Both Forskolin and 8-Br-cAMPS elevate CYP11A1 mRNA levels in the interstitial cell monolayer, which has a fully functional adenylate cyclase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cholesterol 20-22 desmolase; Cholesterol desmolase; cholesterol monooxygenase (side-chain cleaving); cholesterol side chain cleavage; cholesterol side-chain cleavage cytochrome P450; cholesterol side-chain cleavage enzyme P450scc (EC 1.14.15.67); Cholesterol side-chain cleavage enzyme, mitochondrial; CYPXIA1; cytochrome P-450 cholesterol side-chain cleavage enzyme; cytochrome P450 11a cholesterol side chain cleavage; Cytochrome P450 11A1; cytochrome P450 family 11 subfamily A polypeptide 1; cytochrome P450 side-chain cleavage enzyme; cytochrome P450 subfamily 11A; Cytochrome P450(scc); cytochrome P450, 11a, cholesterol side-chain cleavage; cytochrome P450, subfamily XIA (cholesterol side chain cleavage); P450 cholesterol side chain cleavage protein; P450(scc); steroid 20-22-lyase; unnamed protein product

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Gene Aliases: cscc; CYP11A; Cyp11a-1; CYP11A1; CYPXIA1; D9Ertd411e; P450SCC; Scc; SSC

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UniProt ID: (Pig) P10612, (Human) P05108, (Rat) P14137, (Mouse) Q9QZ82

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Entrez Gene ID: (Pig) 403329, (Human) 1583, (Rat) 29680, (Mouse) 13070

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Function(s)
iron ion binding cholesterol monooxygenase (side-chain-cleaving) activity heme binding monooxygenase activity protein binding steroid hydroxylase activity oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen metal ion binding cholesterol binding
Process(es)
organic acid metabolic process steroid biosynthetic process C21-steroid hormone biosynthetic process progesterone biosynthetic process estrogen biosynthetic process response to nutrient mating behavior cholesterol metabolic process male gonad development response to salt stress response to organic substance response to ionizing radiation response to gamma radiation Schwann cell differentiation response to organic cyclic compound response to insecticide biphenyl metabolic process dibenzo-p-dioxin metabolic process phenol-containing compound metabolic process phthalate metabolic process cerebellum development hippocampus development response to vitamin E Leydig cell differentiation response to L-ascorbic acid response to genistein response to gonadotropin response to drug response to hydrogen peroxide response to amino acid response to alkaloid response to peptide hormone response to estrogen cellular response to fibroblast growth factor stimulus response to antibiotic response to cadmium ion response to steroid hormone response to corticosterone response to cAMP oxidation-reduction process granulosa cell differentiation maternal process involved in female pregnancy response to fungicide testosterone biosynthetic process cellular response to lipopolysaccharide cellular response to antibiotic cellular response to cadmium ion cellular response to cAMP cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to gonadotropin stimulus cellular response to follicle-stimulating hormone stimulus cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus alcohol metabolic process lipid metabolic process glucocorticoid biosynthetic process steroid metabolic process C21-steroid hormone metabolic process sterol metabolic process cortisol metabolic process vitamin D metabolic process steroid hormone biosynthetic process
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