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Invitrogen
VMAT2 Polyclonal Antibody
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FIGURE: 1 / 4
VMAT2 Antibody (PA5-102661) in IHC (P)
Immunohistochemistry analysis of VMAT2 in mouse ovarian tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with VMAT2 polyclonal antibody (Product # PA5-102661) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102661
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC18A2(Accession Q05940), corresponding to amino acid residues F449-N499.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SLC18A2.
Target Information
VMAT2 is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. It is a requisite for vesicular amine storage prior to secretion via exocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC120477; MGC120478; MGC26538; monoamine neurotransmitter transporter; monoamine transporter; solute carrier family 18 (vesicular monoamine transporter), member 2; solute carrier family 18 (vesicular monoamine), member 2; Solute carrier family 18 A2 (vesicular monoamine transporter 2); solute carrier family 18 member 2; synaptic vesicle amine transporter, brain; synaptic vesicle monoamine transporter, brain; unnamed protein product; VAT2; vesicle monoamine transporter type 2; vesicle monoamine/H+ antiporter; vesicular amine transporter 2; vesicular monoamine transporter 2
Gene Aliases: 1110037L13Rik; 9330105E13; MNAT; PKDYS2; SVAT; SVMT; VAT2; VMAT-2; VMAT2
UniProt ID: (Human) Q05940, (Mouse) Q8BRU6, (Rat) Q01827
Entrez Gene ID: (Human) 6571, (Mouse) 214084, (Rat) 25549
serotonin secretion by mast cell
histamine secretion by mast cell
neurotransmitter transport
chemical synaptic transmission
aminergic neurotransmitter loading into synaptic vesicle
serotonin uptake
histamine uptake
establishment of localization in cell
transmembrane transport
neurotransmitter loading into synaptic vesicle
somato-dendritic dopamine secretion
hydrogen ion transmembrane transport
negative regulation of reactive oxygen species biosynthetic process
response to amphetamine
locomotory behavior
response to toxic substance
post-embryonic development
regulation of transmembrane transporter activity
insulin secretion
negative regulation of neurotransmitter transport
norepinephrine uptake
cellular response to xenobiotic stimulus
dopamine uptake
response to xenobiotic stimulus
response to herbicide
response to metal ion
response to zinc ion
endocytic recycling
response to cocaine
response to starvation
response to corticosterone
cellular response to ammonium ion
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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