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Invitrogen
SETD2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-102710
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SETD2(Accession Q9BYW2), corresponding to amino acid residues R507-S557.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SETD2.
Target Information
Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: contains WW domain; FLJ16420; FLJ22472; FLJ23184; FLJ45883; huntingtin interacting protein 1; huntingtin yeast partner B; huntingtin-interacting protein B; HYPB; contains WW domain; lysine N-methyltransferase 3A; protein-lysine N-methyltransferase SETD2; SET domain-containing protein 2; unnamed protein product
Gene Aliases: 4921524K10Rik; HBP231; HIF-1; HIP-1; HSPC069; HYPB; KMT3A; LLS; MRD70; p231HBP; RAPAS; SET2
UniProt ID: (Human) Q9BYW2, (Mouse) E9Q5F9
Entrez Gene ID: (Human) 29072, (Rat) 316013, (Mouse) 235626
angiogenesis
vasculogenesis
morphogenesis of a branching structure
neural tube closure
mismatch repair
regulation of transcription, DNA-templated
transcription elongation from RNA polymerase II promoter
response to metal ion
regulation of gene expression
positive regulation of autophagy
regulation of double-strand break repair via homologous recombination
regulation of mRNA export from nucleus
peptidyl-lysine trimethylation
forebrain development
regulation of cytokinesis
positive regulation of interferon-alpha production
response to type I interferon
nucleosome organization
cell migration involved in vasculogenesis
endodermal cell differentiation
response to alkaloid
positive regulation of ossification
mesoderm morphogenesis
embryonic organ development
embryonic cranial skeleton morphogenesis
stem cell differentiation
stem cell development
defense response to virus
pericardium development
embryonic placenta morphogenesis
coronary vasculature morphogenesis
microtubule cytoskeleton organization involved in mitosis
regulation of protein localization to chromatin
autophagosome assembly
proteasomal protein catabolic process
protein K48-linked ubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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