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Invitrogen
CD275 (B7-H2) Polyclonal Antibody
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FIGURE: 1 / 2
CD275 (B7-H2) Antibody (PA5-103092) in ICC/IF
Immunocytochemistry analysis of CD275 (B7-H2) in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with CD275 (B7-H2) polyclonal antibody (Product # PA5-103092) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conj... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-103092
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ICOSLG(Accession O75144), corresponding to amino acid residues L222-A272.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ICOSLG.
Target Information
Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B7 homolog 2; B7 homologue 2; B7-like protein Gl50; B7-related protein 1; B7RP-1; costimulatory surface molecule; ICOS-ligand; ICOS-ligand; transmembrane protein B7-H2 ICOS ligand; unnamed protein product
Gene Aliases: B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275; GI50; GL50; GL50-B; ICOS-L; ICOSL; Icoslg; IMD119; LICOS; Ly115l; mKIAA0653
UniProt ID: (Human) O75144, (Mouse) Q9JHJ8
Entrez Gene ID: (Human) 23308, (Mouse) 50723
regulation of cytokine production
defense response
hyperosmotic response
signal transduction
positive regulation of activated T cell proliferation
T cell activation
T cell receptor signaling pathway
T follicular helper cell differentiation
positive regulation of interleukin-4 production
isotype switching
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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