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Invitrogen
SLC24A2 Polyclonal Antibody
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FIGURE: 1 / 2
SLC24A2 Antibody (PA5-104164) in IHC (P)
Immunohistochemistry analysis of SLC24A2 in human gastric cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with SLC24A2 polyclonal antibody (Product # PA5-104164) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-104164
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC24A2(Accession Q9UI40), corresponding to amino acid residues P311-L361.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SLC24A2.
Target Information
NCKX2, also designated solute carrier family 24, member 2 (SLC24A2), belongs to a family of potassium-dependent sodium/calcium exchangers, all of which contain two large hydrophilic loops and two sets of multiple transmembrane-spanning segments. NCKX2 is expressed in neurons throughout the brain, with high expression found in cone photoreceptors in the retina as well as hippocampal pyramidal cells and the deep nuclei of the cerebellum. A critical component in the process of light adaptation, NCKX2 transports one calcium ion and one potassium ion in exchange for four sodium ions, thereby contolling calcium concentration in the eye during light and darkness. Additionally, NCKX2 regulates calcium levels in other cellular locations that experience rapid calcium fluxes, such as neuronal synapses. Inactivation of NCKX2 is believed to be an important regulatory mechanism in the control of sodium and calcium levels under different physiological conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Na(+)/K(+)/Ca(2+)-exchange protein 2; Na/Ca-K exchanger 2; NCKX family member; NCKX2; potassium-dependent sodium-calcium exchanger; retinal cone Na-Ca+K exchanger; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; solute carrier family 24 member 2; unnamed protein product
Gene Aliases: 2810021B17Rik; 6330417K15Rik; NCKX2
UniProt ID: (Human) Q9UI40, (Mouse) Q8BUN9, (Rat) O54701
Entrez Gene ID: (Human) 25769, (Mouse) 76376, (Rat) 84550
calcium ion transport
cellular calcium ion homeostasis
phototransduction
learning
memory
ion transmembrane transport
sodium ion transmembrane transport
cone photoresponse recovery
transmembrane transport
long-term synaptic potentiation
long term synaptic depression
protein-containing complex assembly
calcium ion import
calcium ion transmembrane transport
cellular response to high light intensity
potassium ion transmembrane transport
calcium ion import across plasma membrane
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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