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Invitrogen
Phospho-Connexin 43 (Ser262) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-Connexin 43 (Ser262) Antibody (PA5-104562) in WB
Western blot analysis of Phospho-Connexin 43 (Ser262) in extracts from SNB19 cells treated with TPA. Samples were incubated with Phospho-Connexin 43 (Ser262) polyclonal antibody (Product # PA5-104562). Lane 1 was treated with phospho-blocking peptide, Lane 2 was treated with non-phospho-blocking peptide.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-104562
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human GJA1(Accession P17302), corresponding to amino acid residues around phosphorylated Ser262.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of Connexin 43 / GJA1 only when phosphorylated at Ser262.
Target Information
Connexin 43 (Cx43), encoded by the GJA1 gene, is a widely expressed gap junction protein that plays an important role in direct cell-to-cell communication. Six Cx43 proteins assemble to form a connexon, or hemichannel, which can pair with a connexon on a neighboring cell to create a gap junction channel. These channels allow ions, metabolites, and small signaling molecules to pass between adjacent cells, helping coordinate processes such as electrical conduction, tissue development, wound healing, and cellular homeostasis. Cx43 is especially abundant in tissues such as the heart, brain, bone, and skin, and changes in its expression, localization, or function have been associated with cardiovascular disease, neurological disorders, impaired tissue repair, and cancer. Because of its broad role in intercellular signaling and disease biology, Cx43 is an important target for studying gap junction function and developing potential therapeutic strategies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: connexin-43; Cx-43; CXA1; DFNB38; gap junction 43 kDa heart protein; gap junction protein, alpha 1, 43kDa; GJA1; ODD; ODOD; SDTY3; Syndactyly type III; unnamed protein product
Gene Aliases: AVSD3; CMDR; CX43; EKVP; EKVP3; GJAL; HLHS1; HSS; ODDD; PPKCA
UniProt ID: (Human) P17302
Entrez Gene ID: (Human) 2697
receptor binding
gap junction channel activity
protein binding
beta-catenin binding
ion transmembrane transporter activity
efflux transmembrane transporter activity
tubulin binding
transmembrane transporter activity
glutathione transmembrane transporter activity
alpha-tubulin binding
beta-tubulin binding
gap junction hemi-channel activity
gap junction channel activity involved in cardiac conduction electrical coupling
scaffold protein binding
gap junction channel activity involved in cell communication by electrical coupling
protein tyrosine kinase binding
establishment of mitotic spindle orientation
cardiac conduction system development
cell communication
signal transduction
cell-cell signaling
spermatogenesis
heart development
protein localization
male gonad development
positive regulation of gene expression
cell communication by electrical coupling
glutamate secretion
gap junction assembly
negative regulation of cell growth
negative regulation of gonadotropin secretion
ion transmembrane transport
glutathione transmembrane transport
maintenance of blood-brain barrier
T cell proliferation
T cell activation
xenobiotic transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
cell-cell junction organization
bone remodeling
transmembrane transport
bone development
cellular response to pH
atrial cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
microtubule-based transport
positive regulation of cold-induced thermogenesis
export across plasma membrane
negative regulation of trophoblast cell migration
regulation of blood circulation
cellular response to beta-amyloid
positive regulation of vascular smooth muscle cell proliferation
positive regulation of morphogenesis of an epithelium
positive regulation of mesodermal cell differentiation
positive regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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