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Invitrogen

Phospho-Fyn (Tyr531) Polyclonal Antibody

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Phospho-Fyn (Tyr531) Polyclonal Antibody

Product Details

PA5-104756

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human Fyn around the phosphorylation site of Tyr530.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816229

Product Specific Information

Antibody detects endogenous levels of Fyn only when phosphorylated at Tyr531, which site historically referenced as Tyr530.

Target Information

FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory. FYN is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: C syn protooncogene; c-syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; Fyn proto-oncogene; kinase Fyn; MGC45350; OKT3-induced calcium influx regulator; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; p59fyn; proto-oncogene c-Fyn; proto-oncogene Syn; proto-oncogene tyrosine-protein kinase Fyn; Protooncogene Syn; RP1-66H14.1; Src Kinase p59; Src like kinase; src-like kinase; src-like tyrosine kinase (put.); putative; src/yes-related novel; tyrosine kinase p59fyn(T); unnamed protein product

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Gene Aliases: p59-FYN; SLK; SYN

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UniProt ID: (Human) P06241, (Rat) Q62844, (Mouse) P39688

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Entrez Gene ID: (Human) 2534, (Rat) 25150, (Mouse) 14360

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Function(s)
G-protein coupled receptor binding protein kinase activity protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding tubulin binding phospholipase activator activity enzyme binding type 5 metabotropic glutamate receptor binding T cell receptor binding CD4 receptor binding CD8 receptor binding identical protein binding alpha-tubulin binding phospholipase binding phosphatidylinositol 3-kinase binding ion channel binding macromolecular complex binding ephrin receptor binding tau protein binding tau-protein kinase activity peptide hormone receptor binding growth factor receptor binding scaffold protein binding disordered domain specific binding
Process(es)
response to singlet oxygen stimulatory C-type lectin receptor signaling pathway negative regulation of inflammatory response to antigenic stimulus heart process calcium ion transport transmembrane receptor protein tyrosine kinase signaling pathway G-protein coupled glutamate receptor signaling pathway axon guidance learning feeding behavior regulation of cell shape response to xenobiotic stimulus negative regulation of gene expression negative regulation of hydrogen peroxide biosynthetic process negative regulation of angiogenesis peptidyl-tyrosine phosphorylation natural killer cell activation cell differentiation T cell costimulation intracellular signal transduction reelin-mediated signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis response to cocaine negative regulation of neuron apoptotic process vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway modulation of synaptic transmission T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of T cell activation leukocyte migration positive regulation of protein kinase B signaling cellular response to hydrogen peroxide cellular response to growth factor stimulus cellular response to peptide hormone stimulus positive regulation of protein targeting to membrane dendritic spine maintenance regulation of glutamate receptor signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of dendritic spine maintenance response to amyloid-beta cellular response to beta-amyloid cellular response to L-glutamate cellular response to glycine positive regulation of protein localization to membrane regulation of calcium ion import across plasma membrane negative regulation of extrinsic apoptotic signaling pathway in absence of ligand neuron migration protein phosphorylation cell surface receptor signaling pathway gene expression positive regulation of neuron projection development forebrain development negative regulation of protein ubiquitination ionotropic glutamate receptor signaling pathway cellular response to platelet-derived growth factor stimulus negative regulation of protein catabolic process positive regulation of tyrosine phosphorylation of STAT protein response to ethanol protein autophosphorylation dendrite morphogenesis activated T cell proliferation detection of mechanical stimulus involved in sensory perception of pain cellular response to transforming growth factor beta stimulus positive regulation of protein localization to nucleus myelination
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