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Invitrogen

Phospho-Met (Tyr1234) Polyclonal Antibody

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Phospho-Met (Tyr1234) Polyclonal Antibody

Product Details

PA5-104777

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MET(Accession P08581), corresponding to amino acid residues around phosphorylated Tyr1234.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816250

Product Specific Information

Antibody detects endogenous levels of c-Met only when phosphorylated at Tyrosine 1234.

Target Information

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Met; cMet; EC 2.7.10.1; HGF receptor; HGF-SF receptor; HGF/SF receptor; met oncogene; MET proto-oncogene protein; met proto-oncogene tyrosine kinase; oncogene MET; protein-tyrosine kinase (EC 2.7.1.112); proto-oncogene c-Met; sc MET; scatter factor receptor; SF receptor; soluble c met; transmembrane tyrosine kinase/hepatocyte growth factor receptor; tyrosine kinase; hepatocyte growth factor receptor; HGFR; tyrosine-protein kinase Met; unnamed protein product

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Gene Aliases: AUTS9; c-Met; DA11; DFNB97; HGF; HGFR; Par4; RCCP2

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UniProt ID: (Human) P08581, (Rat) P97523

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Entrez Gene ID: (Human) 4233, (Mouse) 17295, (Rat) 24553

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity hepatocyte growth factor-activated receptor activity protein binding ATP binding semaphorin receptor activity protein phosphatase binding identical protein binding molecular function activator activity beta-catenin binding phospholipase binding phosphatidylinositol 3-kinase binding macromolecular complex binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter neuron migration endothelial cell morphogenesis liver development placenta development transmembrane receptor protein tyrosine kinase signaling pathway chemical synaptic transmission brain development muscle organ development skeletal muscle tissue development regulation of gene expression positive regulation of gene expression negative regulation of gene expression positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation positive regulation of glucose transport positive regulation of neuron projection development muscle cell migration myotube differentiation regulation of anatomical structure morphogenesis neuron differentiation sperm motility adult behavior pancreas development positive regulation of microtubule polymerization regulation of interleukin-6 production positive regulation of peptidyl-serine phosphorylation negative regulation of Rho protein signal transduction glucose homeostasis positive regulation of MAPK cascade positive regulation of DNA replication positive regulation of mitotic nuclear division positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation hepatocyte growth factor receptor signaling pathway cell development branching morphogenesis of an epithelial tube positive regulation of dendrite morphogenesis modulation of synaptic transmission positive chemotaxis myoblast proliferation negative regulation of stress fiber assembly cardiac muscle cell development cardiac muscle contraction excitatory postsynaptic potential regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling establishment of skin barrier negative regulation of thrombin receptor signaling pathway semaphorin-plexin signaling pathway negative regulation of transforming growth factor beta production reactive oxygen species metabolic process regulation of cellular response to oxidative stress positive regulation of p38MAPK cascade negative regulation of hydrogen peroxide-mediated programmed cell death positive regulation of endothelial cell chemotaxis cell surface receptor signaling pathway negative regulation of autophagy lactation male gonad development response to xenobiotic stimulus response to acidic pH oligodendrocyte development central nervous system neuron differentiation response to peptide hormone cellular response to arsenic-containing substance cellular response to glucose stimulus cellular response to interleukin-6 cellular response to growth factor stimulus cellular response to peptide hormone stimulus regulation of plasma membrane bounded cell projection organization
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