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Phospho-ErbB4 (Tyr984) Polyclonal Antibody

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Phospho-ErbB4 (Tyr984) Polyclonal Antibody

Product Details

PA5-105213

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ERBB4(Accession Q15303), corresponding to amino acid residues around phosphorylated Tyr984.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816686

Product Specific Information

Antibody detects endogenous levels of HER4 only when phosphorylated at Tyr984.

Target Information

Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine subfamily that includes EGFR, ERBB2, and ERBB3. ERBB4 binds and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases). ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. ErbB 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361. Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; avian erythroblastosis oncogene B 4; c-erbB-4; ERBB4; human epidermal growth factor receptor 4; membrane tyrosine kinase; OTTHUMP00000209432; proto-oncogene-like protein c-ErbB-4; receptor tyrosine kinase; tyrosine kinase-type cell surface receptor HER4; unnamed protein product; v-erb-a erythroblastic leukemia viral oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4

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Gene Aliases: ALS19; c-erbB-4; HER4; p180erbB4

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UniProt ID: (Human) Q15303, (Mouse) Q61527, (Rat) Q62956

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Entrez Gene ID: (Human) 2066, (Mouse) 13869, (Rat) 59323

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Function(s)
transcription regulatory region sequence-specific DNA binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity epidermal growth factor-activated receptor activity epidermal growth factor receptor binding protein binding ATP binding neuregulin receptor activity protein homodimerization activity GABA receptor binding neuregulin binding
Process(es)
neural crest cell migration signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway JAK-STAT cascade nervous system development synapse assembly heart development lactation positive regulation of cell proliferation negative regulation of cell proliferation embryonic pattern specification regulation of signal transduction positive regulation of cell communication negative regulation of muscle cell apoptotic process cell migration peptidyl-tyrosine phosphorylation telencephalon development central nervous system morphogenesis olfactory bulb interneuron differentiation positive regulation of signaling neuron differentiation regulation of cell migration positive regulation of cell migration mammary gland development positive regulation of synaptic transmission, GABAergic peptidyl-tyrosine autophosphorylation ERBB2 signaling pathway ERBB4 signaling pathway ERBB2-ERBB4 signaling pathway ERBB4-ERBB4 signaling pathway positive regulation of tyrosine phosphorylation of STAT protein positive regulation of apoptotic process negative regulation of apoptotic process surfactant homeostasis positive regulation of MAPK cascade mitochondrial fragmentation involved in apoptotic process cell fate commitment positive regulation of transcription, DNA-templated positive regulation of phosphate metabolic process positive regulation of glucose import positive regulation of JAK-STAT cascade protein autophosphorylation positive regulation of epithelial cell proliferation positive regulation of protein kinase B signaling positive regulation of cardiac muscle cell proliferation synapse maturation mammary gland epithelial cell differentiation mammary gland alveolus development cardiac muscle tissue regeneration positive regulation of ERK1 and ERK2 cascade positive regulation of phospholipid biosynthetic process cellular response to epidermal growth factor stimulus establishment of planar polarity involved in nephron morphogenesis modulation of excitatory postsynaptic potential neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of dendritic spine maintenance positive regulation of protein localization to cell surface negative regulation of neuron migration positive regulation of protein phosphorylation response to stress female pregnancy response to xenobiotic stimulus response to muscle activity response to nutrient levels response to progesterone response to vitamin D multicellular organismal response to stress response to hydrogen peroxide cellular response to mechanical stimulus response to dexamethasone cellular response to acetylcholine cellular response to L-glutamate
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