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Invitrogen
Phospho-MUSK (Tyr751) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-MUSK (Tyr751) Antibody (PA5-105381) in WB
Western blot analysis of Phospho-MUSK (Tyr751) in extracts from 3T3-l1 cells (heat-shock treatment). Samples were incubated with Phospho-MUSK (Tyr751) polyclonal antibody (Product # PA5-105381). The lane on the left was treated with blocking peptide.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105381
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MUSK(Accession O15146), corresponding to amino acid residues around phosphorylated Tyr751.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of MuSK only when phosphorylated at Tyr751.
Target Information
MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn. Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells. Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor. MuSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC126323; MGC126324; muscle localized kinase 2; muscle specific kinase (neural fold/somite kinase 1); muscle, skeletal, receptor tyrosine kinase; muscle-specific kinase receptor; muscle-specific tyrosine kinase receptor MuSK; muscle-specific tyrosine protein kinase receptor; muscle-specific tyrosine-protein kinase receptor; MuSK; Nsk2; RP23-170A3.1
Gene Aliases: CMS9; FADS; Mdk4; Mlk; Nsk1; Nsk2; Nsk3
UniProt ID: (Human) O15146, (Rat) Q62838, (Mouse) Q61006
Entrez Gene ID: (Human) 4593, (Rat) 81725, (Mouse) 18198
positive regulation of protein phosphorylation
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
neuromuscular junction development
memory
regulation of synaptic growth at neuromuscular junction
positive regulation of gene expression
positive regulation of Rac protein signal transduction
skeletal muscle acetylcholine-gated channel clustering
positive regulation of skeletal muscle acetylcholine-gated channel clustering
positive regulation of protein geranylgeranylation
regulation of transcription, DNA-templated
negative regulation of gene expression
response to muscle activity
positive regulation of synaptic transmission, cholinergic
receptor clustering
positive regulation of neuron apoptotic process
positive regulation of synaptic growth at neuromuscular junction
protein autophosphorylation
response to axon injury
positive regulation of peptidyl-tyrosine phosphorylation
response to electrical stimulus
retina development in camera-type eye
long-term synaptic potentiation
cochlea development
signal transduction
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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