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Phospho-ErbB2 (HER-2) (Tyr1005) Polyclonal Antibody

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Phospho-ErbB2 (HER-2) (Tyr1005) Polyclonal Antibody

Product Details

PA5-105451

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ERBB2(Accession P04626), corresponding to amino acid residues around phosphorylated Tyr1005.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816879

Product Specific Information

Antibody detects endogenous levels of HER2/ErbB2 only when phosphorylated at Tyr1005.

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: approximately 68 kDa secreted autoinhibitor glycoprotein; avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; erbB2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; metastatic lymph node gene 19 protein; Neu oncogene; neu oncogene; p185; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185 precursor; neu/erbB-2; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; proto-oncogene NEU; receptor tyrosine-protein kinase erbB-2-like; tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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Gene Aliases: c-ERB-2; c-ERB2; c-erbB2; c-neu; CD340; Erbb-2; HER-2; HER-2/neu; HER2; HER2/neu; l11Jus8; mKIAA3023; MLN 19; MLN-19; NEU; NGL; p185(erbB2); TKR1; VSCN2

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UniProt ID: (Human) P04626, (Mouse) P70424

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Entrez Gene ID: (Human) 2064, (Mouse) 13866, (Rat) 24337

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Function(s)
RNA polymerase I core binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity transmembrane signaling receptor activity receptor binding protein binding ATP binding coreceptor activity growth factor binding receptor tyrosine kinase binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity ubiquitin protein ligase binding macromolecular complex binding Hsp90 protein binding
Process(es)
signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway nervous system development peripheral nervous system development heart development neuromuscular junction development motor neuron axon guidance cell proliferation positive regulation of cell proliferation glial cell differentiation positive regulation of gene expression Schwann cell development peptidyl-tyrosine phosphorylation neuron differentiation positive regulation of cell growth axon regeneration regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus positive regulation of Rho protein signal transduction intracellular signal transduction ERBB signaling pathway ERBB2-ERBB3 signaling pathway ERBB2-EGFR signaling pathway ERBB2-ERBB4 signaling pathway wound healing regulation of cell proliferation myelination negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade protein kinase B signaling estrous cycle positive regulation of translation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction protein autophosphorylation sympathetic nervous system development animal organ development response to axon injury oligodendrocyte differentiation positive regulation of epithelial cell proliferation positive regulation of small GTPase mediated signal transduction positive regulation of protein kinase B signaling regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus semaphorin-plexin signaling pathway positive regulation of protein targeting to membrane neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of membrane permeability positive regulation of neural precursor cell proliferation liver development skeletal muscle tissue development female pregnancy response to xenobiotic stimulus response to muscle activity response to progesterone response to vitamin D multicellular organismal response to stress tongue development regulation of cell differentiation mammary gland involution cellular response to mechanical stimulus response to dexamethasone protein phosphorylation enzyme linked receptor protein signaling pathway ERBB2 signaling pathway regulation of angiogenesis
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