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FIGURE: 1 / 3
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Antibody detects endogenous levels of GSK3 beta only when phosphorylated at Ser25.
GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 2.7.11.26; FA; factor A; GSK 3 beta; GSK 3B; GSK-3 beta; GSK-3 beta GSK3B; GSK-3b; GSK3 beta; GSK3B; kinase; mGSK3beta; pp37; serine/threonine-protein kinase GSK3B; unnamed protein product
Gene Aliases: 7330414F15Rik; 8430431H08Rik; GSK-3; GSK-3beta; GSK3
UniProt ID: (Human) P49841, (Mouse) Q9WV60, (Rat) P18266
Entrez Gene ID: (Human) 2932, (Mouse) 56637, (Rat) 84027
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