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Invitrogen
Phospho-SQSTM1 (Ser266) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-SQSTM1 (Ser266) Antibody (PA5-105638) in WB
Western blot analysis of Phospho-SQSTM1 (Ser266) in HeLa treated with 2204M MG-132 (18 hr) (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-SQSTM1 (Ser266) polyclonal antibody (Product # PA5-105638).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105638
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SQSTM1(Accession Q13501), corresponding to amino acid residues around phosphorylated Ser266.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of SQSTM1/p62 only when phosphorylated at Ser266.
Target Information
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: autophagy receptor p62; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; oxidative stress induced; oxidative stress induced like; p62 transcript variant 4; p62 transcript variant 5; phosphotyrosine independent ligand for the Lck SH2 domain p62; phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; PKC-zeta-interacting protein; protein kinase C-zeta-interacting protein; ubiquitin-binding protein p62; unnamed protein product
Gene Aliases: A170; DMRV; EBIAP; FTDALS3; NADGP; OSF-6; Osi; OSIL; p60; p62; p62B; PDB3; STAP; STONE14; ZIP; ZIP3
UniProt ID: (Human) Q13501, (Mouse) Q64337, (Rat) O08623
Entrez Gene ID: (Human) 8878, (Mouse) 18412, (Rat) 113894
protein kinase C binding
protein binding
zinc ion binding
enzyme binding
protein kinase binding
protein binding, bridging
receptor tyrosine kinase binding
ubiquitin protein ligase binding
ionotropic glutamate receptor binding
signaling receptor activity
SH2 domain binding
identical protein binding
ubiquitin binding
macromolecular complex binding
K63-linked polyubiquitin binding
ubiquitin-dependent protein binding
protein sequestering activity
molecular sequestering activity
molecular condensate scaffold activity
transcription cofactor activity
signaling adaptor activity
negative regulation of transcription from RNA polymerase II promoter
mitophagy
pexophagy
temperature homeostasis
positive regulation of protein phosphorylation
response to ischemia
protein phosphorylation
ubiquitin-dependent protein catabolic process
protein import into nucleus
autophagy
endosome organization
positive regulation of autophagy
macroautophagy
protein catabolic process
negative regulation of protein ubiquitination
cellular response to stress
toll-like receptor 4 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
aggrephagy
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex stability
brown fat cell proliferation
protein K63-linked ubiquitination
protein targeting to vacuole involved in autophagy
energy homeostasis
response to mitochondrial depolarisation
negative regulation of ferroptosis
membraneless organelle assembly
positive regulation of long-term synaptic potentiation
positive regulation of protein localization to plasma membrane
protein localization to perinuclear region of cytoplasm
mitophagy
protein localization
regulation of mitochondrion organization
endosomal transport
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
regulation of Ras protein signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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