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Invitrogen
Phospho-TYK2 (Tyr1054) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-105746
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TYK2(Accession P29597), corresponding to amino acid residues around phosphorylated Tyr1054.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of TYK2 only when phosphorylated at Tyr1054.
Target Information
Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; tyrosine kinase TYK2; unnamed protein product
Gene Aliases: IMD35; JTK1
UniProt ID: (Human) P29597, (Mouse) Q9R117
Entrez Gene ID: (Human) 7297, (Mouse) 54721
protein phosphorylation
JAK-STAT cascade
cell proliferation
cytokine-mediated signaling pathway
regulation of cell-cell adhesion
cell differentiation
intracellular signal transduction
interleukin-12-mediated signaling pathway
interleukin-5-mediated signaling pathway
interleukin-23-mediated signaling pathway
positive regulation of T cell proliferation
positive regulation of cell adhesion
regulation of JAK-STAT cascade
regulation of alpha-beta T cell activation
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
interleukin-10-mediated signaling pathway
positive regulation of protein localization to nucleus
regulation of transcription from RNA polymerase II promoter
immune response
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
positive regulation of JAK-STAT cascade
regulation of T cell activation
positive regulation of NK T cell proliferation
regulation of leukocyte cell-cell adhesion
positive regulation of T-helper 17 type immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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