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Invitrogen

Phospho-ErbB3 (Tyr1328) Polyclonal Antibody

View all (100) Her-3 (ErbB3) antibodies

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Phospho-ErbB3 (Tyr1328) Polyclonal Antibody

Product Details

PA5-105792

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ERBB3(Accession P21860), corresponding to amino acid residues around phosphorylated Tyr1328.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817191

Product Specific Information

Antibody detects endogenous levels of HER3/ErbB3 only when phosphorylated at Tyr1328.

Target Information

ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6. 2kb mRNA which is translated into a 160/180 kDa glycoprotein. The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity. Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation. Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: avian erythroblastosis oncogene B 3; avian erythroblastosis oncogene B 3 receptor; c-erbB-3; c-erbB3; C-errB-3; epidermal growth factor receptor precursor; erbB3; glial growth factor receptor; HER3 protein precursor; human epidermal growth factor receptor 3; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; tyrosine kinase-type cell surface receptor HER3; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3

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Gene Aliases: c-erbB-3; c-erbB3; ErbB-3; erbB3-S; Erbb3r; FERLK; HER3; LCCS2; MDA-BF-1; nuc-ErbB3; p180-ErbB3; p45-sErbB3; p85-sErbB3; VSCN1

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UniProt ID: (Human) P21860, (Rat) Q62799, (Mouse) Q61526

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Entrez Gene ID: (Human) 2065, (Rat) 29496, (Mouse) 13867

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane signaling receptor activity protein binding ATP binding growth factor binding protein tyrosine kinase activator activity ubiquitin protein ligase binding signaling receptor activity neuregulin receptor activity neuregulin binding identical protein binding ErbB-3 class receptor binding protein heterodimerization activity transmembrane receptor protein tyrosine kinase activity
Process(es)
negative regulation of cell adhesion signal transduction transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway peripheral nervous system development heart development neuromuscular junction development negative regulation of signal transduction Schwann cell differentiation Schwann cell development cranial nerve development neuron differentiation ERBB signaling pathway ERBB2-ERBB3 signaling pathway wound healing regulation of cell proliferation myelination negative regulation of apoptotic process positive regulation of MAPK cascade protein kinase B signaling negative regulation of neuron apoptotic process positive regulation of JNK cascade positive regulation of epithelial cell proliferation negative regulation of secretion neuron apoptotic process positive regulation of protein kinase B signaling extrinsic apoptotic signaling pathway in absence of ligand endocardial cushion development nervous system development axonogenesis skeletal muscle tissue development circadian rhythm response to xenobiotic stimulus positive regulation of gene expression cellular response to insulin stimulus tongue development positive regulation of glucose import animal organ development positive regulation of cardiac muscle tissue development mammary gland involution positive regulation of calcineurin-NFAT signaling cascade cellular response to mechanical stimulus positive regulation of membrane permeability ERBB2 signaling pathway
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