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Invitrogen

Phospho-EphB1/EphB2 (Tyr778, Tyr780) Polyclonal Antibody

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Phospho-EphB1/EphB2 (Tyr778, Tyr780) Polyclonal Antibody

Product Details

PA5-106133

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human EPHB1(Accession P54762), corresponding to amino acid residues around phosphorylated Tyr778.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817531

Product Specific Information

Antibody detects endogenous levels of EPHB1/2 only when phosphorylated at Tyr778/Tyr780.

Target Information

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase family. The protein encoded by this gene is a receptor for ephrin-B family members.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: developmentally-regulated Eph-related tyrosine kinase; EK6; ELK-related protein tyrosine kinase; elk-related tyrosine kinase; Eph receptor B2 (ELK-related protein tyrosine kinase); eph tyrosine kinase 2; eph tyrosine kinase 3; EPH-like kinase 5; EPH-like kinase 6; EPHB3; Ephrin B1; Ephrin B2; ephrin type-B receptor 2-like; EphrinB1; EphrinB2; ETK2; FLJ37986; HEK-6; HEK2; membrane protein; MGC87492; neural kinase; neuronally-expressed EPH-related tyrosine kinase; nuk receptor tyrosine kinase; protein-tyrosine kinase HEK5; renal carcinoma antigen NY-REN-47; Sek-3; TYRO6; tyrosine-protein kinase receptor EPH-2; tyrosine-protein kinase receptor EPH-3; tyrosine-protein kinase receptor SEK-3; tyrosine-protein kinase TYRO5; unnamed protein product

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Gene Aliases: 9330129L11; BDPLT22; C130099E04Rik; CAPB; Cek5; Cek6; DRT; EK5; ELK; Elkh; Ephb2; EPHT2; EPHT3; ERK; ETECK; Hek5; Hek6; NET; Nuk; PCBC; Prkm5; Qek5; RGD1564232; Sek3; Tyro5

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UniProt ID: (Human) P54762, (Human) P29323, (Mouse) Q8CBF3, (Rat) P09759, (Mouse) P54763

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Entrez Gene ID: (Human) 2047, (Human) 2048, (Mouse) 270190, (Rat) 24338, (Mouse) 13844, (Rat) 313633

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Function(s)
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding axon guidance receptor activity macromolecular complex binding beta-amyloid binding receptor binding signaling receptor activity identical protein binding
Process(es)
angiogenesis urogenital system development positive regulation of immunoglobulin production negative regulation of cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway nervous system development axon guidance axonal fasciculation learning or memory learning positive regulation of gene expression phosphorylation peptidyl-tyrosine phosphorylation hindbrain tangential cell migration corpus callosum development regulation of blood coagulation positive regulation of cell migration positive regulation of B cell proliferation positive regulation of synaptic plasticity positive regulation of tumor necrosis factor production B cell activation inner ear morphogenesis regulation of JAK-STAT cascade negative regulation of Ras protein signal transduction ephrin receptor signaling pathway regulation of neuronal synaptic plasticity regulation of body fluid levels positive regulation of multicellular organismal process regulation of filopodium assembly regulation of synapse assembly positive regulation of synapse assembly palate development dendritic spine development dendritic spine morphogenesis positive regulation of dendritic spine morphogenesis negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide commissural neuron axon guidance postsynaptic membrane assembly neuron projection retraction vesicle-mediated intercellular transport tight junction assembly negative regulation of cytokine production involved in inflammatory response positive regulation of long-term synaptic potentiation negative regulation of glutamate receptor signaling pathway positive regulation of glutamate receptor signaling pathway positive regulation of protein localization to plasma membrane cellular response to beta-amyloid neuron projection maintenance positive regulation of protein localization to cell surface regulation of T-helper 17 type immune response regulation of behavioral fear response immunological synapse formation cell activation skeletal muscle satellite cell activation cell migration cranial nerve development optic nerve morphogenesis central nervous system projection neuron axonogenesis neurogenesis establishment of cell polarity retinal ganglion cell axon guidance cell-substrate adhesion regulation of JNK cascade protein autophosphorylation camera-type eye morphogenesis regulation of developmental process modulation of synaptic transmission detection of temperature stimulus involved in sensory perception of pain cell chemotaxis neural precursor cell proliferation regulation of ERK1 and ERK2 cascade negative regulation of skeletal muscle satellite cell proliferation negative regulation of satellite cell differentiation cell morphogenesis protein phosphorylation central nervous system development organ morphogenesis positive regulation of long-term neuronal synaptic plasticity regulation of axonogenesis negative regulation of axonogenesis regulation of autophagosome assembly system development animal organ development
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