Search

  • Contáctenos
  • Orden Rápida

Invitrogen

Phospho-TGFBR1 (Thr204) Polyclonal Antibody

View all (24) TGFBR1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Phospho-TGFBR1 (Thr204) Polyclonal Antibody

Product Details

PA5-106155

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TGFBR1(Accession P36897), corresponding to amino acid residues around phosphorylated Thr204.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817553

Product Specific Information

Antibody detects endogenous levels of TGFBR1 only when phosphorylated at Thr204.

Target Information

TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; activin receptor-like kinase 5; mutant transforming growth factor beta receptor I; ser; serine/threonine-protein kinase receptor R4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1-like; TGF-beta type I receptor; Tgfbr1; TGFR1; Transfor; transforming growth factor beta receptor I; transforming growth factor, beta receptor I; transforming growth factor-beta receptor type I; unnamed protein product

View more View less

Gene Aliases: AAT5; ACVRLK4; ALK-5; ALK5; ESK2; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TbetaR-I; TbetaRI; TBR-i; TBRI; TGFR-1

View more View less

UniProt ID: (Human) P36897, (Mouse) Q64729, (Rat) P80204

View more View less

Entrez Gene ID: (Human) 7046, (Mouse) 21812, (Rat) 29591

View more View less

Function(s)
protein kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type I receptor binding type II transforming growth factor beta receptor binding protein binding ATP binding activin receptor activity, type I growth factor binding ubiquitin protein ligase binding SMAD binding activin binding transforming growth factor beta binding I-SMAD binding macromolecular complex binding
Process(es)
skeletal system development in utero embryonic development kidney development epithelial to mesenchymal transition positive regulation of endothelial cell proliferation ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis proepicardium development regulation of transcription, DNA-templated signal transduction transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway nervous system development heart development positive regulation of cell proliferation germ cell migration anterior/posterior pattern specification regulation of gene expression positive regulation of gene expression regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition peptidyl-serine phosphorylation collagen fibril organization positive regulation of cell growth regulation of cell migration positive regulation of cell migration negative regulation of cell migration regulation of protein ubiquitination negative regulation of chondrocyte differentiation activin receptor signaling pathway intracellular signal transduction myofibroblast differentiation wound healing endothelial cell activation extracellular structure organization positive regulation of apoptotic process positive regulation of transcription, DNA-templated thymus development neuron fate commitment embryonic cranial skeleton morphogenesis skeletal system morphogenesis mesenchymal cell differentiation artery morphogenesis cell motility positive regulation of stress fiber assembly regulation of cell cycle positive regulation of protein kinase B signaling parathyroid gland development palate development pharyngeal system development regulation of cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition positive regulation of SMAD protein import into nucleus ventricular septum morphogenesis angiogenesis involved in coronary vascular morphogenesis coronary artery morphogenesis trophoblast cell migration response to cholesterol cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to alcohol vascular endothelial cell proliferation positive regulation of extracellular matrix assembly positive regulation of mesenchymal stem cell proliferation positive regulation of vasculature development positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of occluding junction disassembly epicardium morphogenesis regulation of multicellular organismal development positive regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway angiogenesis blastocyst development negative regulation of endothelial cell proliferation lens development in camera-type eye protein phosphorylation male gonad development post-embryonic development response to lipid negative regulation of apoptotic process endothelial cell migration response to estrogen negative regulation of cell differentiation negative regulation of endothelial cell differentiation protein autophosphorylation positive regulation of filopodium assembly SMAD protein signal transduction negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter response to hypoxia embryo implantation response to toxic substance lung development organ regeneration response to prostaglandin E digestive tract development response to electrical stimulus
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support