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Invitrogen
WISP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-106451
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human WISP1(Accession O95388), corresponding to amino acid residues I337-N367.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total WISP1.
Target Information
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ELM-1; expressed in low metastatic cells 1; unnamed protein product; WISP-1; WISP1 3'UTR-associated RNA 1; WISP1 overlapping transcript 1 (non-protein coding); WISP1vx; WNT1 induced secreted protein 1; WNT1 inducible signaling pathway protein 1
Gene Aliases: Elm1; WISP1; WISP1-OT1; WISP1-UT1; WISP1c; WISP1i; WISP1tc
UniProt ID: (Human) O95388, (Mouse) O54775, (Rat) Q99PP0
Entrez Gene ID: (Human) 8840, (Mouse) 22402, (Rat) 65154
osteoblast differentiation
regulation of cytokine production
cell adhesion
signal transduction
positive regulation of smooth muscle cell migration
positive regulation of Wnt signaling pathway
osteoclast differentiation
negative regulation of chondrocyte differentiation
glucose homeostasis
regulation of cell differentiation
positive regulation of cell differentiation
negative regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
regulation of multicellular organismal process
bone development
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of wound healing
cell-cell signaling
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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